TY - JOUR
T1 - Reactive oxygen species, thiols and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics
AU - Li, Jun
AU - Zhang, Yi
AU - Wang, Pengzhan
AU - Yu, Le
AU - An, Jusung
AU - Deng, Ganzhen
AU - Sun, Yao
AU - Seung Kim, Jong
N1 - Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998 ,J.S.K.), and NSFC ( 21806048 , 31972744 ), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).
Funding Information:
This work was supported by grants from National Research Foundation of Korea (CRI project: 2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.), and NSFC (21806048,31972744), and the Fundamental Research Funds for the Central Universities (No. 2662018QD009), Wuhan Scientific and Technological Projects (2019020701011441), the Research Fund Program of Guangdong Key Laboratory of Radioactive and Rare Resource Utilization (NO. 2019-LRRRU03), Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology (No: OHIC2019K01). The Key Laboratory of Spectroscopy Sensing, Ministry of Agriculture and Rural Affairs, P. R. China (2020ZJUGP003).
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.
AB - Reactive oxygen species (ROS), thiols and enzymes are regarded as important biomarkers in the physiological process. The abnormal levels of the above species are associated with many diseases, developing a fluorescence detection method for biomarkers is of great significance for diseases early diagnosis and therapy. Compared with traditional fluorescent dyes, aggregation-induced emission (AIE) based fluorescent emitters display excellent photostability with minimum aggregation caused quenching (ACQ) effect. Thus, the biomarker-activable AIEgens have attracted much attentions in biomedical research. In addition, many AIE emitters not only act as fluorescent dyes, but serve as promising theranostic agents. The AIE based image-guided multifunctional theranostics under the activation of biomarkers are vital to the precise biomedicine. This view focuses on the recent development of ROS, thiols, and enzymes activable AIEgens from single fluorescence imaging to multifunctional theranostics.
KW - Activable AIEgens
KW - Aggregation-induced emission
KW - Fluorescence Imaging
KW - Small-molecule dye
KW - Theranostics
UR - http://www.scopus.com/inward/record.url?scp=85090933435&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2020.213559
DO - 10.1016/j.ccr.2020.213559
M3 - Review article
AN - SCOPUS:85090933435
SN - 0010-8545
VL - 427
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213559
ER -