Real time OFF-ON monitoring of gluthathione (GSH) in living cell

Jae Hong Lee, Amit Sharma, Joo Hee Jang, Weon Sup Shin, Joung Hae Lee, Jong Seung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A simple chemodosimetric probe (1) is reported which detects Glutathione (GSH) selectively over other relevant biological species under physiological condition by turning on its fluorescence through the imine hydrolysis reaction. The probe has also been used for imaging of GSH in the live cells by confocal microscopy. Graphical Abstract This report discloses pyrene-based chemodosimetric probe which exhibit a selective response toward Glutathione (GSH) over other biological thiols and was successfully applied to the imaging of GSH in living cells.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume82
Issue number1
DOIs
Publication statusPublished - 2015 Jun 1

Fingerprint

glutathione
Glutathione
Cells
image analysis
Imines
Monitoring
probes
monitoring
thiols
Sulfhydryl Compounds
Confocal Microscopy
Imaging techniques
Hydrolysis
Confocal microscopy
hydrolysis
Fluorescence
pyrenes
fluorescence
cells
imines

Keywords

  • Chemodosimetric
  • Fluorescence
  • Glutathione (GSH)
  • Imine-hydrolysis

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Food Science
  • Chemistry(all)

Cite this

Real time OFF-ON monitoring of gluthathione (GSH) in living cell. / Lee, Jae Hong; Sharma, Amit; Jang, Joo Hee; Shin, Weon Sup; Lee, Joung Hae; Kim, Jong Seung.

In: Journal of Inclusion Phenomena and Macrocyclic Chemistry, Vol. 82, No. 1, 01.06.2015, p. 117-122.

Research output: Contribution to journalArticle

Lee, Jae Hong ; Sharma, Amit ; Jang, Joo Hee ; Shin, Weon Sup ; Lee, Joung Hae ; Kim, Jong Seung. / Real time OFF-ON monitoring of gluthathione (GSH) in living cell. In: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2015 ; Vol. 82, No. 1. pp. 117-122.
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