Real-time phase-contrast imaging of photothermal treatment of head and neck squamous cell carcinoma: An in vitro study of macrophages as a vector for the delivery of gold nanoshells

Taeseok Daniel Yang, Wonshik Choi, Tai Hyun Yoon, Kyoung Jin Lee, Jae Seung Lee, Sang Hun Han, Min Goo Lee, Hong Soon Yim, Kyung Min Choi, Min Woo Park, Kwang Yoon Jung, Seung Kuk Baekd

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22 Citations (Scopus)

Abstract

Photothermal treatment (PTT) using nanoparticles has gained attention as a promising alternative therapy for malignant tumors. One strategy for increasing the selectivity of PTT is the use of macrophages as a cellular vector for delivering nanoparticles. The aim of the present study is to examine the use of macrophages as a cellular vector for efficient PTT and determine the appropriate irradiation power and time of a near-infrared (NIR) laser using realtime phase-contrast imaging. Thermally induced injury and death of cancer cells were found to begin at 44°C to 45°C, which was achieved using the PTT effect with gold nanoshells (NS) and irradiation with a NIR laser at a power of 2 W for 5 min. The peritoneal macrophage efficiently functioned as a cellular vector for the NS, and the cancer cells surrounding the NS-loaded macrophages selectively lost their cellular viability after being irradiated with the NIR laser.

Original languageEnglish
Article number128003
JournalJournal of biomedical optics
Volume17
Issue number12
DOIs
Publication statusPublished - 2012 Dec

Keywords

  • Gold nanoshells
  • Macrophage
  • Photothermal treatment
  • Real-time imaging
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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