Abstract
Real-time, sensitive and specific analysis of gene transcription: The interactions between promoter and RNA polymerase that lead to gene transcription are monitored using Rayleigh light scattering of gold nanoparticle. We can simply detect which base pair of point-mutated promoter is important for the specific recognition by RNA polymerase. This is the first attempt to analyze transcription activity, based on the optical property of single gold nanoparticle.
| Original language | English |
|---|---|
| Pages (from-to) | 1265-1269 |
| Number of pages | 5 |
| Journal | Advanced Materials |
| Volume | 25 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 Mar 6 |
Keywords
- DNA-protein interaction
- gene transcription
- nanoplasmonic biosensor
- promoter activity
- real-time analysis
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
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Song, M. S., Choi, S. P., Lee, J., Kwon, Y. J., & Sim, S. J. (2013). Real-time, sensitive, and specific detection of promoter-polymerase interactions in gene transcription using a nanoplasmonic sensor. Advanced Materials, 25(9), 1265-1269. https://doi.org/10.1002/adma.201203467