Realization of Wafer-Scale Hyperlens Device for Sub-diffractional Biomolecular Imaging

Dasol Lee, Yang Doo Kim, Minkyung Kim, Sunae So, Hak Jong Choi, Jungho Mun, Duc Minh Nguyen, Trevon Badloe, Jong G. Ok, Kyunghoon Kim, Heon Lee, Junsuk Rho

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A hyperlens is a super-resolution optical imaging device based on unique hyperbolic dispersions making the sub-diffraction-limited information on objects propagate to the far-field. Here, we propose a new device consisting of a 4-inch wafer-scale spherical hyperlens array that allows high-throughput and easy-to-handle real-time biomolecular imaging. With this proposed device, we report the first experimental demonstration of real-time sub-diffraction-limited biomolecular imaging using a hyperlens. Hippocampal neuron cells are imaged using a hyperlens at a resolution down to 151 nm, much smaller than the diffraction limit of conventional imaging systems in the visible wavelength. These wafer-scale hyperlens devices have great potential for simple, compact, and low-cost integration with conventional optics and therefore a large variety of imaging applications in biology, pathology, medical science and general nanoscience.

Original languageEnglish
Pages (from-to)2549-2554
Number of pages6
JournalACS Photonics
Volume5
Issue number7
DOIs
Publication statusPublished - 2018 Jul 18

Keywords

  • diffraction limit
  • far-field imaging
  • hyperbolic metamaterials
  • hyperlens
  • super-resolution imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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  • Cite this

    Lee, D., Kim, Y. D., Kim, M., So, S., Choi, H. J., Mun, J., Nguyen, D. M., Badloe, T., Ok, J. G., Kim, K., Lee, H., & Rho, J. (2018). Realization of Wafer-Scale Hyperlens Device for Sub-diffractional Biomolecular Imaging. ACS Photonics, 5(7), 2549-2554. https://doi.org/10.1021/acsphotonics.7b01182