Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells

Jin Il Kim, Ilseob Lee, Sehee Park, Joon Yong Bae, Kirim Yoo, Philippe Lemey, Mee Sook Park, Jin Won Song, Sun-Ho Kee, Ki-Joon Song, Man-Seong Park

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and HA is more important for viral replication than that between PB2 and HA. However, co-adaptation of PB1-PB2-HA genes appears to be affected by complete gene constellation.

Original languageEnglish
Article number27480
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Jun 8

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Influenza B virus
Reassortant Viruses
Genes
Human Influenza
Plasmids
Viruses

ASJC Scopus subject areas

  • General

Cite this

Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells. / Kim, Jin Il; Lee, Ilseob; Park, Sehee; Bae, Joon Yong; Yoo, Kirim; Lemey, Philippe; Park, Mee Sook; Song, Jin Won; Kee, Sun-Ho; Song, Ki-Joon; Park, Man-Seong.

In: Scientific Reports, Vol. 6, 27480, 08.06.2016.

Research output: Contribution to journalArticle

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AU - Yoo, Kirim

AU - Lemey, Philippe

AU - Park, Mee Sook

AU - Song, Jin Won

AU - Kee, Sun-Ho

AU - Song, Ki-Joon

AU - Park, Man-Seong

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