Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells

Jin Il Kim, Ilseob Lee, Sehee Park, Joon Yong Bae, Kirim Yoo, Philippe Lemey, Mee Sook Park, Jin Won Song, Sun Ho Kee, Ki Joon Song, Man Seong Park

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Abstract

In addition to influenza A subtypes, two distinct lineages of influenza B virus also cause seasonal epidemics to humans. Recently, Dudas et al. have done evolutionary analyses of reassortment patterns of the virus and suggested genetic lineage relationship between PB1, PB2, and HA genes. Using genetic plasmids and reassortant viruses, we here demonstrate that a homologous lineage PB1-PB2 pair exhibits better compatibility than a heterologous one and that the lineage relationship between PB1 and HA is more important for viral replication than that between PB2 and HA. However, co-adaptation of PB1-PB2-HA genes appears to be affected by complete gene constellation.

Original languageEnglish
Article number27480
JournalScientific reports
Volume6
DOIs
Publication statusPublished - 2016 Jun 8

ASJC Scopus subject areas

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    Kim, J. I., Lee, I., Park, S., Bae, J. Y., Yoo, K., Lemey, P., Park, M. S., Song, J. W., Kee, S. H., Song, K. J., & Park, M. S. (2016). Reassortment compatibility between PB1, PB2, and HA genes of the two influenza B virus lineages in mammalian cells. Scientific reports, 6, [27480]. https://doi.org/10.1038/srep27480