Recapitulation of molecular regulators of nuclear motion during cell migration

Alexandra Sneider, Jungwon Hah, Denis Wirtz, Dong-Hwee Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

Original languageEnglish
Pages (from-to)50-62
Number of pages13
JournalCell adhesion & migration
Volume13
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Fingerprint

Cell Movement
Cellular Microenvironment
Stress Fibers
Cell Nucleus
Organelles
Rupture

Keywords

  • Cell migration
  • Cytoskeleton
  • LINC complex
  • Nuclear mechanics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Recapitulation of molecular regulators of nuclear motion during cell migration. / Sneider, Alexandra; Hah, Jungwon; Wirtz, Denis; Kim, Dong-Hwee.

In: Cell adhesion & migration, Vol. 13, No. 1, 01.12.2019, p. 50-62.

Research output: Contribution to journalArticle

Sneider, Alexandra ; Hah, Jungwon ; Wirtz, Denis ; Kim, Dong-Hwee. / Recapitulation of molecular regulators of nuclear motion during cell migration. In: Cell adhesion & migration. 2019 ; Vol. 13, No. 1. pp. 50-62.
@article{bd964e3a24494acc803c970a44ec30d9,
title = "Recapitulation of molecular regulators of nuclear motion during cell migration",
abstract = "Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.",
keywords = "Cell migration, Cytoskeleton, LINC complex, Nuclear mechanics",
author = "Alexandra Sneider and Jungwon Hah and Denis Wirtz and Dong-Hwee Kim",
year = "2019",
month = "12",
day = "1",
doi = "10.1080/19336918.2018.1506654",
language = "English",
volume = "13",
pages = "50--62",
journal = "Cell Adhesion and Migration",
issn = "1933-6918",
publisher = "Landes Bioscience",
number = "1",

}

TY - JOUR

T1 - Recapitulation of molecular regulators of nuclear motion during cell migration

AU - Sneider, Alexandra

AU - Hah, Jungwon

AU - Wirtz, Denis

AU - Kim, Dong-Hwee

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

AB - Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

KW - Cell migration

KW - Cytoskeleton

KW - LINC complex

KW - Nuclear mechanics

UR - http://www.scopus.com/inward/record.url?scp=85061282614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061282614&partnerID=8YFLogxK

U2 - 10.1080/19336918.2018.1506654

DO - 10.1080/19336918.2018.1506654

M3 - Article

C2 - 30261154

AN - SCOPUS:85061282614

VL - 13

SP - 50

EP - 62

JO - Cell Adhesion and Migration

JF - Cell Adhesion and Migration

SN - 1933-6918

IS - 1

ER -