Recent advance in brown adipose physiology and its therapeutic potential

Yun Hee Lee, Young Suk Jung, DalWoong Choi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Brown adipose tissue (BAT) is a specialized thermoregulatory organ that has a critical role in the regulation of energy metabolism. Specifically, energy expenditure can be enhanced by the activation of BAT function and the induction of a BAT-like catabolic phenotype in white adipose tissue (WAT). Since the recent recognition of metabolically active BAT in adult humans, BAT has been extensively studied as one of the most promising targets identified for treating obesity and its related disorders. In this review, we summarize information on the developmental origin of BAT and the progenitors of brown adipocytes in WAT. We explore the transcriptional control of brown adipocyte differentiation during classical BAT development and in WAT browning. We also discuss the neuronal control of BAT activity and summarize the recently identified non-canonical stimulators of BAT that can act independently of β-adrenergic stimulation. Finally, we review new findings on the beneficial effects of BAT activation and development with respect to improving metabolic profiles. We highlight the therapeutic potential of BAT and its future prospects, including pharmacological intervention and cell-based therapies designed to enhance BAT activity and development. Experimental & Molecular Medicine (2014) 46, e78; doi:10.1038/emm.2013.163; published online 21 February 2014.

Original languageEnglish
Article numbere78
JournalExperimental and Molecular Medicine
Volume46
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

Fingerprint

Brown Adipose Tissue
Physiology
Tissue
White Adipose Tissue
Therapeutics
Brown Adipocytes
Energy Metabolism
Molecular Medicine
Chemical activation
Metabolome
Cell- and Tissue-Based Therapy
Adrenergic Agents
Obesity
Medicine

Keywords

  • Brown adipose tissue (BAT)
  • Obesity
  • Progenitors
  • White adipose tissue (WAT)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Clinical Biochemistry

Cite this

Recent advance in brown adipose physiology and its therapeutic potential. / Lee, Yun Hee; Jung, Young Suk; Choi, DalWoong.

In: Experimental and Molecular Medicine, Vol. 46, No. 2, e78, 01.02.2014.

Research output: Contribution to journalArticle

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