Recent advances in biocompatible semiconductor nanocrystals for immunobiological applications

Sitansu Sekhar Nanda, Min Jik Kim, Kwang Meyung Kim, Georgia C. Papaefthymiou, Subramanian Tamil Selvan, Dong Kee Yi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Quantum confinement in inorganic semiconductor nanocrystals produces brightly luminescent nanoparticles endowed with unique photo-physical properties, such as tunable optical properties. These have found widespread applications in nanotechnology. The ability to render such nanostructures biocompatible, while maintaining their tunable radiation in the visible range of the electromagnetic spectrum, renders them appropriate for bio-applications. Promising in vitro and in vivo diagnostic applications have been demonstrated, such as fluorescence-based detection of biological interactions, single molecule tracking, multiplexing and immunoassaying. In particular, these fluorescent inorganic semiconductor nanocrystals, generally known as quantum dots, have the potential of remarkable immunobiological applications. This review focuses on the current status of biocompatible quantum dots and their applications in immunobiology − immunosensing, immunofluorescent imaging and immunotherapy.

Original languageEnglish
Pages (from-to)644-654
Number of pages11
JournalColloids and Surfaces B: Biointerfaces
Volume159
DOIs
Publication statusPublished - 2017 Nov 1
Externally publishedYes

    Fingerprint

Keywords

  • Immunoassay
  • Immunofluorescent imaging
  • Immunosensor
  • Immunotherapy
  • Quantum dots

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this