Recent advances in exosome‐based drug delivery for cancer therapy

Hyosuk Kim, Hochung Jang, Haeun Cho, Jiwon Choi, Kwang Yeon Hwang, Yeonho Choi, Sun Hwa Kim, Yoosoo Yang

Research output: Contribution to journalReview articlepeer-review

Abstract

Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocom-patibility and low immunogenicity for efficient delivery of therapeutic agents such as chemothera-peutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of ex-osome‐based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.

Original languageEnglish
Article number4435
JournalCancers
Volume13
Issue number17
DOIs
Publication statusPublished - 2021 Sep 1

Keywords

  • Cancer therapy
  • Drug delivery system
  • Exosome
  • Exosome engineering

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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