Recent advances in microfluidic platelet function assays: Moving microfluidics into clinical applications

Hoyoon Lee, Wonwhi Na, Byoung Kwon Lee, Chae Seung Lim, Sehyun Shin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The analysis of platelet aggregation and thrombosis kinetics has significantly advanced with progress in microfluidic technology. However, the results of platelet aggregation tests do not fully reflect the observed clinical outcomes. To address the present unmet clinical needs, the basic but essential biology of platelets should be reconsidered in relation to the characteristics of microfluidic systems employed for platelet tests. To this end, the present article provides an overview of commercially available point of care devices and focuses on recent microfluidic studies, describing their measurement principles. We critically discuss the characteristics of the microfluidics systems used to evaluate the complex processes underlying platelet aggregation, and that are specifically designed to mimic the pathophysiological environment of blood vessels, including hemodynamic factors as well as blood vessel injury. To this end, we summarize unsolved issues related to the application of platelet function tests based on microfluidics. Overall, we confirm that platelet function tests based on microfluidics provide a versatile platform that encompasses a variety of basic research, as well as clinical diagnostic applications.

Original languageEnglish
Pages (from-to)249-266
Number of pages18
JournalClinical Hemorheology and Microcirculation
Volume71
Issue number2
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • diagnostic
  • function
  • microfluidic
  • Platelets
  • test

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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