Recent advances in NSAIDs-induced enteropathy therapeutics

New options, new challenges

Yun Jeong Lim, Hoon-Jai Chun

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Recently, chronic low-dose aspirin consumption was found to be associated with injury to the lower gut and to be a significant contributing factor in small bowel ulceration, hemorrhage, and strictures. The ability of aspirin and NSAIDs to inhibit the activities of cyclooxygenase (COX) contributes to the cytotoxicity of these drugs in the gastrointestinal tract. However, many studies found that, in the small intestine, COX-independent mechanisms are the main contributors to NSAID cytotoxicity. Bile and Gram-negative bacteria are important factors in the pathogenesis of NSAID enteropathy. Here, we focus on a promising strategy to prevent NSAID-induced small intestine injury. Selective COX-2 inhibitors, prostaglandin derivatives, mucoprotective drugs, phosphatidylcholine-NSAIDs, and probiotics have potential protective effects on NSAID enteropathy.

Original languageEnglish
Article number761060
JournalGastroenterology Research and Practice
Volume2013
DOIs
Publication statusPublished - 2013 Oct 16

Fingerprint

Non-Steroidal Anti-Inflammatory Agents
Wounds and Injuries
Small Intestine
Therapeutics
Prostaglandin-Endoperoxide Synthases
Aspirin
Capsule Endoscopy
Cyclooxygenase 2 Inhibitors
Probiotics
Gram-Negative Bacteria
Phosphatidylcholines
Bile
Pharmaceutical Preparations
Prostaglandins
Gastrointestinal Tract
Pathologic Constriction
Hemorrhage

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Recent advances in NSAIDs-induced enteropathy therapeutics : New options, new challenges. / Lim, Yun Jeong; Chun, Hoon-Jai.

In: Gastroenterology Research and Practice, Vol. 2013, 761060, 16.10.2013.

Research output: Contribution to journalReview article

@article{a229319547b04af8ae222dd6d55ea228,
title = "Recent advances in NSAIDs-induced enteropathy therapeutics: New options, new challenges",
abstract = "The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Recently, chronic low-dose aspirin consumption was found to be associated with injury to the lower gut and to be a significant contributing factor in small bowel ulceration, hemorrhage, and strictures. The ability of aspirin and NSAIDs to inhibit the activities of cyclooxygenase (COX) contributes to the cytotoxicity of these drugs in the gastrointestinal tract. However, many studies found that, in the small intestine, COX-independent mechanisms are the main contributors to NSAID cytotoxicity. Bile and Gram-negative bacteria are important factors in the pathogenesis of NSAID enteropathy. Here, we focus on a promising strategy to prevent NSAID-induced small intestine injury. Selective COX-2 inhibitors, prostaglandin derivatives, mucoprotective drugs, phosphatidylcholine-NSAIDs, and probiotics have potential protective effects on NSAID enteropathy.",
author = "Lim, {Yun Jeong} and Hoon-Jai Chun",
year = "2013",
month = "10",
day = "16",
doi = "10.1155/2013/761060",
language = "English",
volume = "2013",
journal = "Gastroenterology Research and Practice",
issn = "1687-6121",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Recent advances in NSAIDs-induced enteropathy therapeutics

T2 - New options, new challenges

AU - Lim, Yun Jeong

AU - Chun, Hoon-Jai

PY - 2013/10/16

Y1 - 2013/10/16

N2 - The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Recently, chronic low-dose aspirin consumption was found to be associated with injury to the lower gut and to be a significant contributing factor in small bowel ulceration, hemorrhage, and strictures. The ability of aspirin and NSAIDs to inhibit the activities of cyclooxygenase (COX) contributes to the cytotoxicity of these drugs in the gastrointestinal tract. However, many studies found that, in the small intestine, COX-independent mechanisms are the main contributors to NSAID cytotoxicity. Bile and Gram-negative bacteria are important factors in the pathogenesis of NSAID enteropathy. Here, we focus on a promising strategy to prevent NSAID-induced small intestine injury. Selective COX-2 inhibitors, prostaglandin derivatives, mucoprotective drugs, phosphatidylcholine-NSAIDs, and probiotics have potential protective effects on NSAID enteropathy.

AB - The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Recently, chronic low-dose aspirin consumption was found to be associated with injury to the lower gut and to be a significant contributing factor in small bowel ulceration, hemorrhage, and strictures. The ability of aspirin and NSAIDs to inhibit the activities of cyclooxygenase (COX) contributes to the cytotoxicity of these drugs in the gastrointestinal tract. However, many studies found that, in the small intestine, COX-independent mechanisms are the main contributors to NSAID cytotoxicity. Bile and Gram-negative bacteria are important factors in the pathogenesis of NSAID enteropathy. Here, we focus on a promising strategy to prevent NSAID-induced small intestine injury. Selective COX-2 inhibitors, prostaglandin derivatives, mucoprotective drugs, phosphatidylcholine-NSAIDs, and probiotics have potential protective effects on NSAID enteropathy.

UR - http://www.scopus.com/inward/record.url?scp=84885357653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885357653&partnerID=8YFLogxK

U2 - 10.1155/2013/761060

DO - 10.1155/2013/761060

M3 - Review article

VL - 2013

JO - Gastroenterology Research and Practice

JF - Gastroenterology Research and Practice

SN - 1687-6121

M1 - 761060

ER -