Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Je Won Park, Yeo Joon Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.

Original languageEnglish
Pages (from-to)445-458
Number of pages14
JournalJournal of Industrial Microbiology and Biotechnology
Volume46
Issue number3-4
DOIs
Publication statusPublished - 2019 Mar 29

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Biosynthesis
Macrolides
Antibiotics
Microorganisms
Metabolic engineering
Polyketide Synthases
Anti-Bacterial Agents
Metabolic Engineering

Keywords

  • 14-Membered macrolide
  • Combinatorial biosynthesis
  • Polyketide synthase
  • Post-polyketide synthase tailoring

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

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