TY - JOUR
T1 - Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
AU - Park, Je Won
AU - Yoon, Yeo Joon
N1 - Funding Information:
Acknowledgements This work was supported by a National Research Foundation of Korea grant (2016R1A2A1A05005078) (Y.J.Y.) funded by the Ministry of Science and ICT, the High Value-Added Food Technology Development Program funded by the Ministry of Agriculture, Food, and Rural Affairs (114019052SB010) (Y.J.Y.), a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare (HI18C1664) (Y.J.Y.), the Collaborative Genome Program of the Korea Institute of Marine Science and Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (MOF) (No.20180430) (Y.J.Y.), and the Cooperative Research Program for Agriculture Science and Technology Development (PJ01317901) (J.W.P.) funded by the Rural Development Administration, Republic of Korea.
Publisher Copyright:
© 2018, Society for Industrial Microbiology and Biotechnology.
PY - 2019/3/29
Y1 - 2019/3/29
N2 - Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.
AB - Macrolides, especially 14-membered macrolides, are a valuable group of antibiotics that originate from various microorganisms. In addition to their antibacterial activity, newly discovered 14-membered macrolides exhibit other therapeutic potentials, such as anti-proliferative and anti-protistal activities. Combinatorial biosynthetic approaches will allow us to create structurally diversified macrolide analogs, which are especially important during the emerging post-antibiotic era. This review focuses on recent advances in the discovery of new 14-membered macrolides (also including macrolactones) from microorganisms and the current status of combinatorial biosynthetic approaches, including polyketide synthase (PKS) and post-PKS tailoring pathways, and metabolic engineering for improved production together with heterologous production of 14-membered macrolides.
KW - 14-Membered macrolide
KW - Combinatorial biosynthesis
KW - Polyketide synthase
KW - Post-polyketide synthase tailoring
UR - http://www.scopus.com/inward/record.url?scp=85056298131&partnerID=8YFLogxK
U2 - 10.1007/s10295-018-2095-4
DO - 10.1007/s10295-018-2095-4
M3 - Article
C2 - 30415291
AN - SCOPUS:85056298131
SN - 1367-5435
VL - 46
SP - 445
EP - 458
JO - Journal of Industrial Microbiology and Biotechnology
JF - Journal of Industrial Microbiology and Biotechnology
IS - 3-4
ER -