TY - JOUR
T1 - Recent Advances in the Synthesis of Intra-Nanogap Au Plasmonic Nanostructures for Bioanalytical Applications
AU - Yang, Wonseok
AU - Lim, Dong Kwon
N1 - Funding Information:
The authors acknowledge financial support from a Korea University Grant and from the KU‐KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF‐2017M3D1A1039421 and 2018R1A2A3075499).
Funding Information:
The authors acknowledge financial support from a Korea University Grant and from the KU-KIST research fund. This research was also supported by the National Research Foundation of Korea (No. NRF-2017M3D1A1039421 and 2018R1A2A3075499).
Publisher Copyright:
© 2020 Wiley-VCH GmbH
PY - 2020/12/22
Y1 - 2020/12/22
N2 - Plasmonic nanogap-enhanced Raman scattering has attracted considerable attention in the fields of Raman-based bioanalytical applications and materials science. Various strategies have been proposed to prepare nanostructures with an inter- or intra-nanogap for fundamental study models or applications. This report focuses on recent advances in synthetic methods to fabricate intra-nanogap structures with diverse dimensions, with detailed focus on the theory and bioanalytical applications. Synthetic strategies ranging from the use of a silica layer to small molecules, the use of polymers and galvanic replacement, are extensively investigated. Furthermore, various core structures, such as spherical, rod-, and cube-shaped, are widely studied, and greatly expand the diversity of plasmonic nanostructures with an intra-nanogap. Theoretical calculations, ranging from the first plasmonic hybridization model that is applied to a concentric Au–SiO2–Au nanosphere to the modern quantum corrected model, have evolved to accurately describe the plasmonic resonance property in concentric core–shell nanostructures with a subnanometer nanogap. The greatly enhanced and uniform Raman responses from the localized Raman reporter in the built-in nanogap have made it possible to achieve promising probes with an extraordinary high sensitivity in various formats, such as biomolecule detection, high-resolution cell imaging, and an in vivo imaging application.
AB - Plasmonic nanogap-enhanced Raman scattering has attracted considerable attention in the fields of Raman-based bioanalytical applications and materials science. Various strategies have been proposed to prepare nanostructures with an inter- or intra-nanogap for fundamental study models or applications. This report focuses on recent advances in synthetic methods to fabricate intra-nanogap structures with diverse dimensions, with detailed focus on the theory and bioanalytical applications. Synthetic strategies ranging from the use of a silica layer to small molecules, the use of polymers and galvanic replacement, are extensively investigated. Furthermore, various core structures, such as spherical, rod-, and cube-shaped, are widely studied, and greatly expand the diversity of plasmonic nanostructures with an intra-nanogap. Theoretical calculations, ranging from the first plasmonic hybridization model that is applied to a concentric Au–SiO2–Au nanosphere to the modern quantum corrected model, have evolved to accurately describe the plasmonic resonance property in concentric core–shell nanostructures with a subnanometer nanogap. The greatly enhanced and uniform Raman responses from the localized Raman reporter in the built-in nanogap have made it possible to achieve promising probes with an extraordinary high sensitivity in various formats, such as biomolecule detection, high-resolution cell imaging, and an in vivo imaging application.
KW - intra-nanogap structures
KW - oligonucleotides
KW - quantum tunneling
KW - small molecules
KW - surface-enhanced Raman scattering
UR - http://www.scopus.com/inward/record.url?scp=85092554084&partnerID=8YFLogxK
U2 - 10.1002/adma.202002219
DO - 10.1002/adma.202002219
M3 - Review article
C2 - 33063429
AN - SCOPUS:85092554084
VL - 32
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 51
M1 - 2002219
ER -