Recent development of biotin conjugation in biological imaging, sensing, and target delivery

Wen Xiu Ren, Jiyou Han, Soojin Uhm, Yu Jin Jang, Chulhun Kang, Jong-Hoon Kim, Jong Seung Kim

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Despite encouraging results from preliminary studies of anticancer therapies, the lack of tumor specificity remains an important issue in the modern pharmaceutical industry. New findings indicate that biotin or biotin-conjugates could be favorably assimilated by tumor cells that over-express biotin-selective transporters. Furthermore, biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. The strong bridging between avidin and biotin moieties on other molecules is a proven adaptable tool with broad biological applications. Under these circumstances, a biotin moiety is certainly an attractive choice for live-cell imaging, biosensing, and target delivery.

Original languageEnglish
Pages (from-to)10403-10418
Number of pages16
JournalChemical Communications
Volume51
Issue number52
DOIs
Publication statusPublished - 2015 Jul 4

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Biotin
Imaging techniques
Avidin
Tumors
Streptavidin
Drug Industry
Neoplasms
Drug products
Cells
Molecules
Pharmaceutical Preparations
Industry
Therapeutics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Recent development of biotin conjugation in biological imaging, sensing, and target delivery. / Ren, Wen Xiu; Han, Jiyou; Uhm, Soojin; Jang, Yu Jin; Kang, Chulhun; Kim, Jong-Hoon; Kim, Jong Seung.

In: Chemical Communications, Vol. 51, No. 52, 04.07.2015, p. 10403-10418.

Research output: Contribution to journalArticle

Ren, Wen Xiu ; Han, Jiyou ; Uhm, Soojin ; Jang, Yu Jin ; Kang, Chulhun ; Kim, Jong-Hoon ; Kim, Jong Seung. / Recent development of biotin conjugation in biological imaging, sensing, and target delivery. In: Chemical Communications. 2015 ; Vol. 51, No. 52. pp. 10403-10418.
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