Recent development of biotin conjugation in biological imaging, sensing, and target delivery

Wen Xiu Ren, Jiyou Han, Soojin Uhm, Yu Jin Jang, Chulhun Kang, Jong-Hoon Kim, Jong Seung Kim

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Despite encouraging results from preliminary studies of anticancer therapies, the lack of tumor specificity remains an important issue in the modern pharmaceutical industry. New findings indicate that biotin or biotin-conjugates could be favorably assimilated by tumor cells that over-express biotin-selective transporters. Furthermore, biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. The strong bridging between avidin and biotin moieties on other molecules is a proven adaptable tool with broad biological applications. Under these circumstances, a biotin moiety is certainly an attractive choice for live-cell imaging, biosensing, and target delivery.

Original languageEnglish
Pages (from-to)10403-10418
Number of pages16
JournalChemical Communications
Volume51
Issue number52
DOIs
Publication statusPublished - 2015 Jul 4

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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