Recent progress in luminescent and colorimetric chemosensors for detection of thiols

Hyo Sung Jung, Xiaoqiang Chen, Jong Seung Kim, Juyoung Yoon

Research output: Contribution to journalArticle

590 Citations (Scopus)


In the past few decades, the development of optical probes for thiols has attracted great attention because of the biological importance of the thiol-containing molecules such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH). This tutorial review focuses on various thiol detection methods based on luminescent or colorimetric spectrophotometry published during the period 2010-2012. The discussion covers a diversity of sensing mechanisms such as Michael addition, cyclization with aldehydes, conjugate addition-cyclization, cleavage of sulfonamide and sulfonate esters, thiol-halogen nucleophilic substitution, disulfide exchange, native chemical ligation (NCL), metal complex-displace coordination, and nanomaterial-related and DNA-based chemosensors. This journal is

Original languageEnglish
Pages (from-to)6019-6031
Number of pages13
JournalChemical Society Reviews
Issue number14
Publication statusPublished - 2013 Jul 21


ASJC Scopus subject areas

  • Chemistry(all)

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