Recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy

Dong Kee Yi, Sitansu Sekhar Nanda, Kwang Meyung Kim, Subramanian Tamil Selvan

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Stem cells offer great potential for regenerative medicine due to their excellent capability to differentiate into a specialized cell type of the human body. Recently, nanomaterial based scaffolds (e.g. graphene), biodegradable polymers (e.g. PLGA: poly-d,l-lactic-co-glycolic acid), and inorganic nanoparticles (NPs, e.g. metallic, magnetic, upconversion) have made considerable advances in controlling the differentiation of stem cells. Some of the notable advances include the development of a variety of NPs such as gold, silica, selenium and graphene quantum dots (QDs) for the controlled differentiation of stem cells-human mesenchymal stem cells (hMSCs), and magnetic core-shell NPs (e.g. ZnFe2O4-Au) for the control of neural stem cells (NSCs). Multimodal imaging (MR, optical, ultrasound, photoacoustic) of stem cells provides opportunities for probing the fate of implanted cells, thereby determining the therapeutic efficacy. Novel multifunctional NPs have been developed over the years, and probed using the aforementioned imaging techniques for stem cell research. This review article underscores the recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy. Nano/biomaterial assisted stem cell therapies for bone, heart, and liver regeneration are also delineated.

Original languageEnglish
Pages (from-to)9429-9451
Number of pages23
JournalJournal of Materials Chemistry B
Volume5
Issue number48
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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