Recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy

Dong Kee Yi, Sitansu Sekhar Nanda, Kwang Meyung Kim, Subramanian Tamil Selvan

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Stem cells offer great potential for regenerative medicine due to their excellent capability to differentiate into a specialized cell type of the human body. Recently, nanomaterial based scaffolds (e.g. graphene), biodegradable polymers (e.g. PLGA: poly-d,l-lactic-co-glycolic acid), and inorganic nanoparticles (NPs, e.g. metallic, magnetic, upconversion) have made considerable advances in controlling the differentiation of stem cells. Some of the notable advances include the development of a variety of NPs such as gold, silica, selenium and graphene quantum dots (QDs) for the controlled differentiation of stem cells-human mesenchymal stem cells (hMSCs), and magnetic core-shell NPs (e.g. ZnFe2O4-Au) for the control of neural stem cells (NSCs). Multimodal imaging (MR, optical, ultrasound, photoacoustic) of stem cells provides opportunities for probing the fate of implanted cells, thereby determining the therapeutic efficacy. Novel multifunctional NPs have been developed over the years, and probed using the aforementioned imaging techniques for stem cell research. This review article underscores the recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy. Nano/biomaterial assisted stem cell therapies for bone, heart, and liver regeneration are also delineated.

Original languageEnglish
Pages (from-to)9429-9451
Number of pages23
JournalJournal of Materials Chemistry B
Volume5
Issue number48
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Fingerprint

Nanotechnology
Cell- and Tissue-Based Therapy
Stem cells
Labeling
Cell Differentiation
Stem Cells
glycolic acid
Graphite
Multimodal Imaging
Stem Cell Research
Quantum Dots
Graphene
Liver Regeneration
Bone Regeneration
Regenerative Medicine
Neural Stem Cells
Nanostructures
Biocompatible Materials
Selenium
Mesenchymal Stromal Cells

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy. / Yi, Dong Kee; Nanda, Sitansu Sekhar; Kim, Kwang Meyung; Tamil Selvan, Subramanian.

In: Journal of Materials Chemistry B, Vol. 5, No. 48, 01.01.2017, p. 9429-9451.

Research output: Contribution to journalReview article

Yi, Dong Kee ; Nanda, Sitansu Sekhar ; Kim, Kwang Meyung ; Tamil Selvan, Subramanian. / Recent progress in nanotechnology for stem cell differentiation, labeling, tracking and therapy. In: Journal of Materials Chemistry B. 2017 ; Vol. 5, No. 48. pp. 9429-9451.
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