Recent progress of intelligent hydrogels for tissue engineering

S. V.Berwin Singh, Dong-Kwon Lim, Gilson Khang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tissue engineering (TE) covers a broad range of applications, including repairing or replacing portions of or whole tissues such as bone, cartilage, blood vessels, bladder, skin, muscle, etc. For effective TE, it requires a thorough knowledge about cells, engineering materials, and suitable biochemical and physiochemical factors to improve or replace biological functions. 1 Tissues require mechanical structural support to adhere, develop, differentiate, and ultimately perform specific biochemical functions. The term “regenerative medicine” is often used synonymously with TE; TE aims to create functional constructs that could improve the function of the 218damaged tissues or whole organs. Regenerative medicine (RM) is an ocean in which TE is a small part of it, RM utilizes the self-healing mechanisms of the body incorporated with a biomaterial to aid in tissue repair. Stem cells are unspecialized quiescent cells which could be reprogrammed and tamed according to our need; 2, 3 TE and RM are emerging as a promising cure for Alzheimer’s, spinal cord injury, muscular dystrophy, rheumatic arthritis, and type 1 diabetes, 4, 5, 6, 7, 8, 9, 10 thereby shifting the paradigm of curing an ailment instead of treating it. Stem cells cannot do a great wonder on its own; it requires a supportive material, that is, scaffold that could hold the stem cell providing an extracellular matrix (ECM) condition such as skeletal framework and growth factors.

Original languageEnglish
Title of host publicationHandbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition
PublisherPan Stanford Publishing Pte. Ltd.
Pages217-241
Number of pages25
ISBN (Electronic)9789814745130
ISBN (Print)9789814745123
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)

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  • Cite this

    Singh, S. V. B., Lim, D-K., & Khang, G. (2017). Recent progress of intelligent hydrogels for tissue engineering. In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition (pp. 217-241). Pan Stanford Publishing Pte. Ltd.. https://doi.org/10.1201/9781315364698