Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology

Muhammad Kashif Rahim, Sung Eun Kim, Hyeongryul So, Hyung Jun Kim, Gi Jeong Cheon, Eun Seong Lee, Keon Wook Kang, Dong Soo Lee

    Research output: Contribution to journalReview articlepeer-review

    71 Citations (Scopus)

    Abstract

    Image quantification studies in positron emission tomography/computed tomography (PET/CT) are of immense importance in the diagnosis and follow-up of variety of cancers. In this review we have described the current image quantification methodologies employed in 18F-fluorodeoxyglucose (18F-FDG) PET in major oncological conditions with particular emphasis on tumor heterogeneity studies. We have described various quantitative parameters being used in PET image analysis. The main contemporary methodology is to measure tumor metabolic activity; however, analysis of other image-related parameters is also increasing. Primarily, we have identified the existing role of tumor heterogeneity studies in major cancers using 18F-FDG PET. We have also described some newer radiopharmaceuticals other than 18F-FDG being studied/used in the management of these cancers. Tumor heterogeneity studies are being performed in almost all major oncological conditions using 18F-FDG PET. The role of these studies is very promising in the management of these conditions.

    Original languageEnglish
    Pages (from-to)1-15
    Number of pages15
    JournalNuclear Medicine and Molecular Imaging
    Volume48
    Issue number1
    DOIs
    Publication statusPublished - 2014 Mar

    Keywords

    • Positron emission tomography
    • Quantification
    • Standard uptake value
    • Textural analysis
    • Tumor heterogeneity studies

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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