Recent Trends in PET Image Interpretations Using Volumetric and Texture-based Quantification Methods in Nuclear Oncology

Muhammad Kashif Rahim, Sung Eun Kim, Hyeongryul So, Hyung Jun Kim, Gi Jeong Cheon, Eun Seong Lee, Keon Wook Kang, Dong Soo Lee

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Image quantification studies in positron emission tomography/computed tomography (PET/CT) are of immense importance in the diagnosis and follow-up of variety of cancers. In this review we have described the current image quantification methodologies employed in 18F-fluorodeoxyglucose (18F-FDG) PET in major oncological conditions with particular emphasis on tumor heterogeneity studies. We have described various quantitative parameters being used in PET image analysis. The main contemporary methodology is to measure tumor metabolic activity; however, analysis of other image-related parameters is also increasing. Primarily, we have identified the existing role of tumor heterogeneity studies in major cancers using 18F-FDG PET. We have also described some newer radiopharmaceuticals other than 18F-FDG being studied/used in the management of these cancers. Tumor heterogeneity studies are being performed in almost all major oncological conditions using 18F-FDG PET. The role of these studies is very promising in the management of these conditions.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalNuclear Medicine and Molecular Imaging
Volume48
Issue number1
DOIs
Publication statusPublished - 2014 Mar

Keywords

  • Positron emission tomography
  • Quantification
  • Standard uptake value
  • Textural analysis
  • Tumor heterogeneity studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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