Recombinant newcastle disease virus as a vaccine vector

T. Nakaya, J. Cros, Man-Seong Park, Y. Nakaya, H. Zheng, A. Sagrera, E. Villar, A. García-Sastre, P. Palese

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Abstract

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

Original languageEnglish
Pages (from-to)11868-11873
Number of pages6
JournalJournal of Virology
Volume75
Issue number23
DOIs
Publication statusPublished - 2001 Nov 26
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Nakaya, T., Cros, J., Park, M-S., Nakaya, Y., Zheng, H., Sagrera, A., Villar, E., García-Sastre, A., & Palese, P. (2001). Recombinant newcastle disease virus as a vaccine vector. Journal of Virology, 75(23), 11868-11873. https://doi.org/10.1128/JVI.75.23.11868-11873.2001