Recombinant newcastle disease virus as a vaccine vector

T. Nakaya, J. Cros, Man-Seong Park, Y. Nakaya, H. Zheng, A. Sagrera, E. Villar, A. García-Sastre, P. Palese

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

Original languageEnglish
Pages (from-to)11868-11873
Number of pages6
JournalJournal of Virology
Volume75
Issue number23
DOIs
Publication statusPublished - 2001 Nov 26
Externally publishedYes

Fingerprint

Newcastle disease virus
Orthomyxoviridae
Vaccines
Viruses
Reverse Genetics
Hemagglutinins
Antibody Formation
Complementary DNA
Clone Cells

ASJC Scopus subject areas

  • Immunology

Cite this

Nakaya, T., Cros, J., Park, M-S., Nakaya, Y., Zheng, H., Sagrera, A., ... Palese, P. (2001). Recombinant newcastle disease virus as a vaccine vector. Journal of Virology, 75(23), 11868-11873. https://doi.org/10.1128/JVI.75.23.11868-11873.2001

Recombinant newcastle disease virus as a vaccine vector. / Nakaya, T.; Cros, J.; Park, Man-Seong; Nakaya, Y.; Zheng, H.; Sagrera, A.; Villar, E.; García-Sastre, A.; Palese, P.

In: Journal of Virology, Vol. 75, No. 23, 26.11.2001, p. 11868-11873.

Research output: Contribution to journalArticle

Nakaya, T, Cros, J, Park, M-S, Nakaya, Y, Zheng, H, Sagrera, A, Villar, E, García-Sastre, A & Palese, P 2001, 'Recombinant newcastle disease virus as a vaccine vector', Journal of Virology, vol. 75, no. 23, pp. 11868-11873. https://doi.org/10.1128/JVI.75.23.11868-11873.2001
Nakaya T, Cros J, Park M-S, Nakaya Y, Zheng H, Sagrera A et al. Recombinant newcastle disease virus as a vaccine vector. Journal of Virology. 2001 Nov 26;75(23):11868-11873. https://doi.org/10.1128/JVI.75.23.11868-11873.2001
Nakaya, T. ; Cros, J. ; Park, Man-Seong ; Nakaya, Y. ; Zheng, H. ; Sagrera, A. ; Villar, E. ; García-Sastre, A. ; Palese, P. / Recombinant newcastle disease virus as a vaccine vector. In: Journal of Virology. 2001 ; Vol. 75, No. 23. pp. 11868-11873.
@article{04f1cf63fcb1435c87a285f6e7c3cdc9,
title = "Recombinant newcastle disease virus as a vaccine vector",
abstract = "A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.",
author = "T. Nakaya and J. Cros and Man-Seong Park and Y. Nakaya and H. Zheng and A. Sagrera and E. Villar and A. Garc{\'i}a-Sastre and P. Palese",
year = "2001",
month = "11",
day = "26",
doi = "10.1128/JVI.75.23.11868-11873.2001",
language = "English",
volume = "75",
pages = "11868--11873",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "23",

}

TY - JOUR

T1 - Recombinant newcastle disease virus as a vaccine vector

AU - Nakaya, T.

AU - Cros, J.

AU - Park, Man-Seong

AU - Nakaya, Y.

AU - Zheng, H.

AU - Sagrera, A.

AU - Villar, E.

AU - García-Sastre, A.

AU - Palese, P.

PY - 2001/11/26

Y1 - 2001/11/26

N2 - A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

AB - A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

UR - http://www.scopus.com/inward/record.url?scp=0035164225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035164225&partnerID=8YFLogxK

U2 - 10.1128/JVI.75.23.11868-11873.2001

DO - 10.1128/JVI.75.23.11868-11873.2001

M3 - Article

VL - 75

SP - 11868

EP - 11873

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 23

ER -