Recombinant newcastle disease virus as a vaccine vector

T. Nakaya, J. Cros, M. S. Park, Y. Nakaya, H. Zheng, A. Sagrera, E. Villar, A. García-Sastre, P. Palese

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.

Original languageEnglish
Pages (from-to)11868-11873
Number of pages6
JournalJournal of virology
Volume75
Issue number23
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Nakaya, T., Cros, J., Park, M. S., Nakaya, Y., Zheng, H., Sagrera, A., Villar, E., García-Sastre, A., & Palese, P. (2001). Recombinant newcastle disease virus as a vaccine vector. Journal of virology, 75(23), 11868-11873. https://doi.org/10.1128/JVI.75.23.11868-11873.2001