Rectum dose analysis employing a multi-purpose brachytherapy phantom

HyunDo D. Huh, WooChul C. Kim, John J K Loh, Suk Lee, Chul Yong Kim, SangHoon H. Lee, DongOh O. Shin, Dongho Shin, SamJu J. Cho, Jisun Jang, Sangwook Lim, Kwang Hwan Cho, Sooil Kwon, SeongHoon H. Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal complications. Methods: A measured dose was administered at rectal reference point R1 using a diode detector in four patients who used a tandem and ovoid in brachytherapy for carcinoma of the cervix. A total number of 20 rectal dose measurements were performed five times per patient. In addition, discrepancies in the set-up of the diode detector were analyzed with each repetitive measurement. After reproducing the same conditions as found in actual therapy using a multi-function applicator (MFA) in the multi-purpose brachytherapy phantom constructed for this study, the dose was measured at reference points in the rectum using a thermoluminescence dosimeter (TLD). Results: According to the discrepancies measured in the set-up using a diode detector, Patient 1 showed a maximum value of 11.25 ± 0.95 mm in the Y direction, Patients 2 and 3 exhibited 9.90 ± 2.40 mm and 20.85 ± 4.50 mm in the Z direction, respectively. Patient 4 showed 19.15 ± 3.33 mm in the Z direction. In addition, values of the mean dose according to the position of the diode detector were recorded as 122.82 ± 7.96-323.78 ± 11.16 cGy. In the measured results for TLD in an MPBP, relative error for Patients 1 and 4 at the rectal reference point R2 were a maximum of 8.6 and 7.7%, respectively. For Patients 2 and 3 they were 1.7 and 1.2%, respectively. Furthermore, the dose measured at point R1 and R2 exhibited values approximately 1.7-8.6% higher than the dose calculated in advance, excluding point R1 in Patient 2. The discrepancies in the set-up owing to repetitive measurements and alterations in dosage according to these changes were not analyzed. It was evident that the relative error between the calculated and measured value was within 15%, which was allowable according to the recommendations by the American Association of Physicists in Medicine (AAPM). Conclusions: The multi-purpose brachytherapy phantom constructed for this study successfully reproduced an optimal dose measured under the same conditions found in actual therapy in which the dose was precisely analyzed at a rectal reference point. In addition, these results were considered reliable and applicable for dose optimization before applying therapy using the measured data from the phantom in order to reduce rectal complications.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalJapanese Journal of Clinical Oncology
Volume37
Issue number5
DOIs
Publication statusPublished - 2007 May 1

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Brachytherapy
Rectum
Therapeutics
Cervix Uteri
Medicine
Carcinoma

Keywords

  • Brachytherapy
  • Diode detect or
  • MFA
  • Multi-purpose brachytherapy phantom (MPBP)
  • TLD

ASJC Scopus subject areas

  • Oncology

Cite this

Rectum dose analysis employing a multi-purpose brachytherapy phantom. / Huh, HyunDo D.; Kim, WooChul C.; Loh, John J K; Lee, Suk; Kim, Chul Yong; Lee, SangHoon H.; Shin, DongOh O.; Shin, Dongho; Cho, SamJu J.; Jang, Jisun; Lim, Sangwook; Cho, Kwang Hwan; Kwon, Sooil; Kim, SeongHoon H.

In: Japanese Journal of Clinical Oncology, Vol. 37, No. 5, 01.05.2007, p. 391-398.

Research output: Contribution to journalArticle

Huh, HD, Kim, WC, Loh, JJK, Lee, S, Kim, CY, Lee, SH, Shin, DO, Shin, D, Cho, SJ, Jang, J, Lim, S, Cho, KH, Kwon, S & Kim, SH 2007, 'Rectum dose analysis employing a multi-purpose brachytherapy phantom', Japanese Journal of Clinical Oncology, vol. 37, no. 5, pp. 391-398. https://doi.org/10.1093/jjco/hym032
Huh, HyunDo D. ; Kim, WooChul C. ; Loh, John J K ; Lee, Suk ; Kim, Chul Yong ; Lee, SangHoon H. ; Shin, DongOh O. ; Shin, Dongho ; Cho, SamJu J. ; Jang, Jisun ; Lim, Sangwook ; Cho, Kwang Hwan ; Kwon, Sooil ; Kim, SeongHoon H. / Rectum dose analysis employing a multi-purpose brachytherapy phantom. In: Japanese Journal of Clinical Oncology. 2007 ; Vol. 37, No. 5. pp. 391-398.
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abstract = "Purpose: It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal complications. Methods: A measured dose was administered at rectal reference point R1 using a diode detector in four patients who used a tandem and ovoid in brachytherapy for carcinoma of the cervix. A total number of 20 rectal dose measurements were performed five times per patient. In addition, discrepancies in the set-up of the diode detector were analyzed with each repetitive measurement. After reproducing the same conditions as found in actual therapy using a multi-function applicator (MFA) in the multi-purpose brachytherapy phantom constructed for this study, the dose was measured at reference points in the rectum using a thermoluminescence dosimeter (TLD). Results: According to the discrepancies measured in the set-up using a diode detector, Patient 1 showed a maximum value of 11.25 ± 0.95 mm in the Y direction, Patients 2 and 3 exhibited 9.90 ± 2.40 mm and 20.85 ± 4.50 mm in the Z direction, respectively. Patient 4 showed 19.15 ± 3.33 mm in the Z direction. In addition, values of the mean dose according to the position of the diode detector were recorded as 122.82 ± 7.96-323.78 ± 11.16 cGy. In the measured results for TLD in an MPBP, relative error for Patients 1 and 4 at the rectal reference point R2 were a maximum of 8.6 and 7.7{\%}, respectively. For Patients 2 and 3 they were 1.7 and 1.2{\%}, respectively. Furthermore, the dose measured at point R1 and R2 exhibited values approximately 1.7-8.6{\%} higher than the dose calculated in advance, excluding point R1 in Patient 2. The discrepancies in the set-up owing to repetitive measurements and alterations in dosage according to these changes were not analyzed. It was evident that the relative error between the calculated and measured value was within 15{\%}, which was allowable according to the recommendations by the American Association of Physicists in Medicine (AAPM). Conclusions: The multi-purpose brachytherapy phantom constructed for this study successfully reproduced an optimal dose measured under the same conditions found in actual therapy in which the dose was precisely analyzed at a rectal reference point. In addition, these results were considered reliable and applicable for dose optimization before applying therapy using the measured data from the phantom in order to reduce rectal complications.",
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AU - Huh, HyunDo D.

AU - Kim, WooChul C.

AU - Loh, John J K

AU - Lee, Suk

AU - Kim, Chul Yong

AU - Lee, SangHoon H.

AU - Shin, DongOh O.

AU - Shin, Dongho

AU - Cho, SamJu J.

AU - Jang, Jisun

AU - Lim, Sangwook

AU - Cho, Kwang Hwan

AU - Kwon, Sooil

AU - Kim, SeongHoon H.

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N2 - Purpose: It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal complications. Methods: A measured dose was administered at rectal reference point R1 using a diode detector in four patients who used a tandem and ovoid in brachytherapy for carcinoma of the cervix. A total number of 20 rectal dose measurements were performed five times per patient. In addition, discrepancies in the set-up of the diode detector were analyzed with each repetitive measurement. After reproducing the same conditions as found in actual therapy using a multi-function applicator (MFA) in the multi-purpose brachytherapy phantom constructed for this study, the dose was measured at reference points in the rectum using a thermoluminescence dosimeter (TLD). Results: According to the discrepancies measured in the set-up using a diode detector, Patient 1 showed a maximum value of 11.25 ± 0.95 mm in the Y direction, Patients 2 and 3 exhibited 9.90 ± 2.40 mm and 20.85 ± 4.50 mm in the Z direction, respectively. Patient 4 showed 19.15 ± 3.33 mm in the Z direction. In addition, values of the mean dose according to the position of the diode detector were recorded as 122.82 ± 7.96-323.78 ± 11.16 cGy. In the measured results for TLD in an MPBP, relative error for Patients 1 and 4 at the rectal reference point R2 were a maximum of 8.6 and 7.7%, respectively. For Patients 2 and 3 they were 1.7 and 1.2%, respectively. Furthermore, the dose measured at point R1 and R2 exhibited values approximately 1.7-8.6% higher than the dose calculated in advance, excluding point R1 in Patient 2. The discrepancies in the set-up owing to repetitive measurements and alterations in dosage according to these changes were not analyzed. It was evident that the relative error between the calculated and measured value was within 15%, which was allowable according to the recommendations by the American Association of Physicists in Medicine (AAPM). Conclusions: The multi-purpose brachytherapy phantom constructed for this study successfully reproduced an optimal dose measured under the same conditions found in actual therapy in which the dose was precisely analyzed at a rectal reference point. In addition, these results were considered reliable and applicable for dose optimization before applying therapy using the measured data from the phantom in order to reduce rectal complications.

AB - Purpose: It is difficult to reproduce a brachytherapy measurement because of changes in the rectal shape during inter-fraction. We constructed a multi-purpose brachytherapy phantom (MPBP) and reproduced the same conditions found in actual therapy. We further attempted to apply the measured optimal dose to reduce rectal complications. Methods: A measured dose was administered at rectal reference point R1 using a diode detector in four patients who used a tandem and ovoid in brachytherapy for carcinoma of the cervix. A total number of 20 rectal dose measurements were performed five times per patient. In addition, discrepancies in the set-up of the diode detector were analyzed with each repetitive measurement. After reproducing the same conditions as found in actual therapy using a multi-function applicator (MFA) in the multi-purpose brachytherapy phantom constructed for this study, the dose was measured at reference points in the rectum using a thermoluminescence dosimeter (TLD). Results: According to the discrepancies measured in the set-up using a diode detector, Patient 1 showed a maximum value of 11.25 ± 0.95 mm in the Y direction, Patients 2 and 3 exhibited 9.90 ± 2.40 mm and 20.85 ± 4.50 mm in the Z direction, respectively. Patient 4 showed 19.15 ± 3.33 mm in the Z direction. In addition, values of the mean dose according to the position of the diode detector were recorded as 122.82 ± 7.96-323.78 ± 11.16 cGy. In the measured results for TLD in an MPBP, relative error for Patients 1 and 4 at the rectal reference point R2 were a maximum of 8.6 and 7.7%, respectively. For Patients 2 and 3 they were 1.7 and 1.2%, respectively. Furthermore, the dose measured at point R1 and R2 exhibited values approximately 1.7-8.6% higher than the dose calculated in advance, excluding point R1 in Patient 2. The discrepancies in the set-up owing to repetitive measurements and alterations in dosage according to these changes were not analyzed. It was evident that the relative error between the calculated and measured value was within 15%, which was allowable according to the recommendations by the American Association of Physicists in Medicine (AAPM). Conclusions: The multi-purpose brachytherapy phantom constructed for this study successfully reproduced an optimal dose measured under the same conditions found in actual therapy in which the dose was precisely analyzed at a rectal reference point. In addition, these results were considered reliable and applicable for dose optimization before applying therapy using the measured data from the phantom in order to reduce rectal complications.

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KW - Diode detect or

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KW - Multi-purpose brachytherapy phantom (MPBP)

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