Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas

Sasha E. Stanton, Sang Won Shin, Bruce E. Johnson, Matthew Meyerson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The genetic lesions that lead to the development of small cell lung carcinoma (SCLC) remain incompletely defined. To identify recurrent allelic deletions in specific chromosomal regions that could serve as markers for tumor suppressor gene (TSG) inactivation in SCLC, we performed a comprehensive allelotype analysis of all 39 nonacrocentric autosomal arms. Alterations in 158 polymorphic microsatellite alleles were examined in 24 pairs of human SCLC tumor and normal control DNA samples. A total of 2,107 informative reactions were analyzed. This analysis revealed allelic losses of 100% on chromosome arm 3p, >85% loss within chromosome arms 13q and 17p, and >70% loss within chromosome arms 4q, 5q, 15q, and 16q. The allelic deletions on chromosome arms 15q and 16q have not been defined previously for SCLC and are candidate regions to harbor novel TSGs.

Original languageEnglish
Pages (from-to)323-331
Number of pages9
JournalGenes Chromosomes and Cancer
Volume27
Issue number3
DOIs
Publication statusPublished - 2000 Mar 1
Externally publishedYes

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Chromosome Deletion
Small Cell Lung Carcinoma
Chromosomes
Loss of Heterozygosity
Gene Silencing
Tumor Suppressor Genes
Microsatellite Repeats
Alleles
DNA
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas. / Stanton, Sasha E.; Shin, Sang Won; Johnson, Bruce E.; Meyerson, Matthew.

In: Genes Chromosomes and Cancer, Vol. 27, No. 3, 01.03.2000, p. 323-331.

Research output: Contribution to journalArticle

Stanton, Sasha E. ; Shin, Sang Won ; Johnson, Bruce E. ; Meyerson, Matthew. / Recurrent allelic deletions of chromosome arms 15q and 16q in human small cell lung carcinomas. In: Genes Chromosomes and Cancer. 2000 ; Vol. 27, No. 3. pp. 323-331.
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