Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i

Kyusik Kang, Tai Hwan Park, Nayoung Kim, Min Uk Jang, Sang Soon Park, Jong Moo Park, Youngchai Ko, Soo Joo Lee, Kyung Bok Lee, Jun Lee, Dong Eog Kim, Yong Jin Cho, Joon Tae Kim, Dae Hyun Kim, Jae Kwan Cha, Moon Ku Han, Ji Sung Lee, Juneyoung Lee, Mi Sun Oh, Jay Chol ChoiByung Chul Lee, Keun Sik Hong, Hee Joon Bae

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9 Citations (Scopus)

Abstract

Background Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular events. The aim of this study was to estimate rates of recurrent stroke, myocardial infarction (MI), and major vascular events during the first year after AIS in Korea. Methods Through a multicenter stroke registry in Korea, 12,227 consecutive cases of AIS were identified between November 2010 and May 2013 and were followed up for recurrent stroke, MI, and major vascular events up to 1 year after stroke. Results Cumulative 30-day, 90-day and 1-year rates were 2.7%, 3.9%, and 5.7% for recurrent stroke;.1%,.3%, and.5% for MI; and 8.1%, 10.6%, and 13.7% for major vascular events, indicating that the early period is at high risk of recurrent stroke and major vascular events. The risk of recurrent stroke was substantially higher than the risk of MI: 13.0 times at 90 days and 11.4 times at 1 year. Compared to those with small-vessel occlusion (SVO), those with ischemic stroke subtypes other than SVO had a higher risk of recurrent stroke as well as major vascular events. Other common independent predictors for recurrent stroke and major vascular events were diabetes and prior stroke history. Conclusions During the first year after AIS, one in 18 had recurrent stroke and one in 7 major vascular events. More than two thirds of recurrent stroke and three quarters of major vascular events developed within 90 days in a Korean cohort of stroke patients. Better prevention strategies are required for high-risk patients during this high-risk period.

Original languageEnglish
Pages (from-to)656-664
Number of pages9
JournalJournal of Stroke and Cerebrovascular Diseases
Volume25
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

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Keywords

  • Ischemic stroke
  • myocardial infarction
  • recurrence
  • stroke subtype
  • vascular death
  • vascular event

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Kang, K., Park, T. H., Kim, N., Jang, M. U., Park, S. S., Park, J. M., Ko, Y., Lee, S. J., Lee, K. B., Lee, J., Kim, D. E., Cho, Y. J., Kim, J. T., Kim, D. H., Cha, J. K., Han, M. K., Lee, J. S., Lee, J., Oh, M. S., ... Bae, H. J. (2016). Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i. Journal of Stroke and Cerebrovascular Diseases, 25(3), 656-664. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.036