Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i

Kyusik Kang, Tai Hwan Park, Nayoung Kim, Min Uk Jang, Sang Soon Park, Jong Moo Park, Youngchai Ko, Soo Joo Lee, Kyung Bok Lee, Jun Lee, Dong Eog Kim, Yong Jin Cho, Joon Tae Kim, Dae Hyun Kim, Jae Kwan Cha, Moon Ku Han, Ji Sung Lee, Juneyoung Lee, Mi Sun Oh, Jay Chol ChoiByung Chul Lee, Keun Sik Hong, Hee Joon Bae

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular events. The aim of this study was to estimate rates of recurrent stroke, myocardial infarction (MI), and major vascular events during the first year after AIS in Korea. Methods Through a multicenter stroke registry in Korea, 12,227 consecutive cases of AIS were identified between November 2010 and May 2013 and were followed up for recurrent stroke, MI, and major vascular events up to 1 year after stroke. Results Cumulative 30-day, 90-day and 1-year rates were 2.7%, 3.9%, and 5.7% for recurrent stroke;.1%,.3%, and.5% for MI; and 8.1%, 10.6%, and 13.7% for major vascular events, indicating that the early period is at high risk of recurrent stroke and major vascular events. The risk of recurrent stroke was substantially higher than the risk of MI: 13.0 times at 90 days and 11.4 times at 1 year. Compared to those with small-vessel occlusion (SVO), those with ischemic stroke subtypes other than SVO had a higher risk of recurrent stroke as well as major vascular events. Other common independent predictors for recurrent stroke and major vascular events were diabetes and prior stroke history. Conclusions During the first year after AIS, one in 18 had recurrent stroke and one in 7 major vascular events. More than two thirds of recurrent stroke and three quarters of major vascular events developed within 90 days in a Korean cohort of stroke patients. Better prevention strategies are required for high-risk patients during this high-risk period.

Original languageEnglish
Pages (from-to)656-664
Number of pages9
JournalJournal of Stroke and Cerebrovascular Diseases
Volume25
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

Fingerprint

Observational Studies
Blood Vessels
Stroke
Myocardial Infarction
Prospective Studies
Recurrence
Korea
Registries

Keywords

  • Ischemic stroke
  • myocardial infarction
  • recurrence
  • stroke subtype
  • vascular death
  • vascular event

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke : The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i. / Kang, Kyusik; Park, Tai Hwan; Kim, Nayoung; Jang, Min Uk; Park, Sang Soon; Park, Jong Moo; Ko, Youngchai; Lee, Soo Joo; Lee, Kyung Bok; Lee, Jun; Kim, Dong Eog; Cho, Yong Jin; Kim, Joon Tae; Kim, Dae Hyun; Cha, Jae Kwan; Han, Moon Ku; Lee, Ji Sung; Lee, Juneyoung; Oh, Mi Sun; Choi, Jay Chol; Lee, Byung Chul; Hong, Keun Sik; Bae, Hee Joon.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 25, No. 3, 01.03.2016, p. 656-664.

Research output: Contribution to journalArticle

Kang, K, Park, TH, Kim, N, Jang, MU, Park, SS, Park, JM, Ko, Y, Lee, SJ, Lee, KB, Lee, J, Kim, DE, Cho, YJ, Kim, JT, Kim, DH, Cha, JK, Han, MK, Lee, JS, Lee, J, Oh, MS, Choi, JC, Lee, BC, Hong, KS & Bae, HJ 2016, 'Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke: The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i', Journal of Stroke and Cerebrovascular Diseases, vol. 25, no. 3, pp. 656-664. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.036
Kang, Kyusik ; Park, Tai Hwan ; Kim, Nayoung ; Jang, Min Uk ; Park, Sang Soon ; Park, Jong Moo ; Ko, Youngchai ; Lee, Soo Joo ; Lee, Kyung Bok ; Lee, Jun ; Kim, Dong Eog ; Cho, Yong Jin ; Kim, Joon Tae ; Kim, Dae Hyun ; Cha, Jae Kwan ; Han, Moon Ku ; Lee, Ji Sung ; Lee, Juneyoung ; Oh, Mi Sun ; Choi, Jay Chol ; Lee, Byung Chul ; Hong, Keun Sik ; Bae, Hee Joon. / Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke : The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i. In: Journal of Stroke and Cerebrovascular Diseases. 2016 ; Vol. 25, No. 3. pp. 656-664.
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T1 - Recurrent Stroke, Myocardial Infarction, and Major Vascular Events during the First Year after Acute Ischemic Stroke

T2 - The Multicenter Prospective Observational Study about Recurrence and Its Determinants after Acute Ischemic Stroke i

AU - Kang, Kyusik

AU - Park, Tai Hwan

AU - Kim, Nayoung

AU - Jang, Min Uk

AU - Park, Sang Soon

AU - Park, Jong Moo

AU - Ko, Youngchai

AU - Lee, Soo Joo

AU - Lee, Kyung Bok

AU - Lee, Jun

AU - Kim, Dong Eog

AU - Cho, Yong Jin

AU - Kim, Joon Tae

AU - Kim, Dae Hyun

AU - Cha, Jae Kwan

AU - Han, Moon Ku

AU - Lee, Ji Sung

AU - Lee, Juneyoung

AU - Oh, Mi Sun

AU - Choi, Jay Chol

AU - Lee, Byung Chul

AU - Hong, Keun Sik

AU - Bae, Hee Joon

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular events. The aim of this study was to estimate rates of recurrent stroke, myocardial infarction (MI), and major vascular events during the first year after AIS in Korea. Methods Through a multicenter stroke registry in Korea, 12,227 consecutive cases of AIS were identified between November 2010 and May 2013 and were followed up for recurrent stroke, MI, and major vascular events up to 1 year after stroke. Results Cumulative 30-day, 90-day and 1-year rates were 2.7%, 3.9%, and 5.7% for recurrent stroke;.1%,.3%, and.5% for MI; and 8.1%, 10.6%, and 13.7% for major vascular events, indicating that the early period is at high risk of recurrent stroke and major vascular events. The risk of recurrent stroke was substantially higher than the risk of MI: 13.0 times at 90 days and 11.4 times at 1 year. Compared to those with small-vessel occlusion (SVO), those with ischemic stroke subtypes other than SVO had a higher risk of recurrent stroke as well as major vascular events. Other common independent predictors for recurrent stroke and major vascular events were diabetes and prior stroke history. Conclusions During the first year after AIS, one in 18 had recurrent stroke and one in 7 major vascular events. More than two thirds of recurrent stroke and three quarters of major vascular events developed within 90 days in a Korean cohort of stroke patients. Better prevention strategies are required for high-risk patients during this high-risk period.

AB - Background Patients with acute ischemic stroke (AIS) are at high risk of subsequent vascular events. The aim of this study was to estimate rates of recurrent stroke, myocardial infarction (MI), and major vascular events during the first year after AIS in Korea. Methods Through a multicenter stroke registry in Korea, 12,227 consecutive cases of AIS were identified between November 2010 and May 2013 and were followed up for recurrent stroke, MI, and major vascular events up to 1 year after stroke. Results Cumulative 30-day, 90-day and 1-year rates were 2.7%, 3.9%, and 5.7% for recurrent stroke;.1%,.3%, and.5% for MI; and 8.1%, 10.6%, and 13.7% for major vascular events, indicating that the early period is at high risk of recurrent stroke and major vascular events. The risk of recurrent stroke was substantially higher than the risk of MI: 13.0 times at 90 days and 11.4 times at 1 year. Compared to those with small-vessel occlusion (SVO), those with ischemic stroke subtypes other than SVO had a higher risk of recurrent stroke as well as major vascular events. Other common independent predictors for recurrent stroke and major vascular events were diabetes and prior stroke history. Conclusions During the first year after AIS, one in 18 had recurrent stroke and one in 7 major vascular events. More than two thirds of recurrent stroke and three quarters of major vascular events developed within 90 days in a Korean cohort of stroke patients. Better prevention strategies are required for high-risk patients during this high-risk period.

KW - Ischemic stroke

KW - myocardial infarction

KW - recurrence

KW - stroke subtype

KW - vascular death

KW - vascular event

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