Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation

A meta-analysis

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation. Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP). Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110–1.265, p =.020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = –0.045–0.439, p =.111). No evidence of elevated MPV in the AS group was found (SMD = –0.005, 95% CI = –0.411–0.400, p =.979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214–0.431, p <.001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283–0.581, p <.001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080–0.346, p =.002). Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.

Original languageEnglish
JournalModern Rheumatology
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Mean Platelet Volume
Erythrocyte Indices
Ankylosing Spondylitis
Meta-Analysis
Blood Platelets
Lymphocytes
Inflammation
C-Reactive Protein
Confidence Intervals
Control Groups
Databases

Keywords

  • ankylosing spondylitis
  • Blood cell count
  • inflammation
  • relationship

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{b9a460416c02485492ebee46f845d381,
title = "Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: A meta-analysis",
abstract = "Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation. Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP). Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95{\%} confidence interval (CI) = 0.110–1.265, p =.020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95{\%} CI = –0.045–0.439, p =.111). No evidence of elevated MPV in the AS group was found (SMD = –0.005, 95{\%} CI = –0.411–0.400, p =.979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95{\%} CI = 0.214–0.431, p <.001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95{\%} CI = 0.283–0.581, p <.001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95{\%} CI = 0.080–0.346, p =.002). Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.",
keywords = "ankylosing spondylitis, Blood cell count, inflammation, relationship",
author = "Song, {Gwan Gyu} and Lee, {Young Ho}",
year = "2019",
month = "1",
day = "1",
doi = "10.1080/14397595.2019.1645373",
language = "English",
journal = "Modern Rheumatology",
issn = "1439-7595",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Lee, Young Ho

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation. Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP). Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110–1.265, p =.020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = –0.045–0.439, p =.111). No evidence of elevated MPV in the AS group was found (SMD = –0.005, 95% CI = –0.411–0.400, p =.979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214–0.431, p <.001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283–0.581, p <.001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080–0.346, p =.002). Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.

AB - Objectives: To evaluate the relationship between red cell distribution width (RDW), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) and ankylosing spondylitis (AS) and establish a correlation between these haematological indices and AS inflammation. Methods: We searched the Medline, Embase, and Cochrane databases, performed a meta-analysis comparing RDW, PLR, and MPV in patients with AS to controls, and examined correlation coefficients between RDW, PLR, and MPV and C-reactive protein (CRP). Results: Eleven studies were included in this meta-analysis, which revealed that RDW was significantly higher in the AS group than in the control group (standardized mean difference (SMD) = 0.687, 95% confidence interval (CI) = 0.110–1.265, p =.020). However, PLR was not significantly higher in the AS group than in the control group (SMD = 0.197, 95% CI = –0.045–0.439, p =.111). No evidence of elevated MPV in the AS group was found (SMD = –0.005, 95% CI = –0.411–0.400, p =.979). Meta-analysis of correlation coefficients revealed that RDW was positively associated with CRP (correlation coefficient = 0.327, 95% CI = 0.214–0.431, p <.001). PLR was positively associated with CRP (correlation coefficient = 0.444, 95% CI = 0.283–0.581, p <.001). In addition, the meta-analysis showed a correlation between MPV and CRP (correlation coefficient = 0.217, 95% CI = 0.080–0.346, p =.002). Conclusion: This meta-analysis demonstrated that RDW is higher in patients with AS, and a significant positive correlation exists between RDW, PLR, and MPV and CRP.

KW - ankylosing spondylitis

KW - Blood cell count

KW - inflammation

KW - relationship

UR - http://www.scopus.com/inward/record.url?scp=85070321209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070321209&partnerID=8YFLogxK

U2 - 10.1080/14397595.2019.1645373

DO - 10.1080/14397595.2019.1645373

M3 - Article

JO - Modern Rheumatology

JF - Modern Rheumatology

SN - 1439-7595

ER -