Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice

Ji Sun Kim, Tae Youl Ha, Suna Kim, Sung-Joon Lee, Jiyun Ahn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Red paprika (Capsicum annuum L.) is a widely used natural food colorant and source of vital micronutrients. The main carotenoid in red paprika is capsanthin. In this study, the effects of red paprika and capsanthin on impaired lipid metabolism were investigated in diet-induced obese mice. Forty male mice were divided into 4 groups; normal diet (ND), high-fat diet (HD), HD with red paprika, and HD with capsanthin. After 8 weeks, the red paprika and capsanthin groups showed significantly reduced weight gain, and ameliorated hypertrophy of the liver and adipose tissues. Red paprika and capsanthin treatment also improved serum lipid profile and adipokine secretion, and ameliorated hepatic steatosis by suppressing hepatic lipogenesis, fatty acid oxidation, and gluconeogenesis. In epididymal adipose tissue, red paprika and capsanthin inhibited adipogenesis and decreased lipid droplet size. Taken together, red paprika and capsanthin could ameliorate the detrimental effects of diet-induced obesity by improving impaired lipid metabolism.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalJournal of Functional Foods
Volume31
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

capsanthin
paprika
Obese Mice
Capsicum
High Fat Diet
Carotenoids
high fat diet
Capsicum annuum
Lipid Metabolism
lipid metabolism
adipose tissue
Adipose Tissue
carotenoids
liver
Liver
mice
Diet
diet
Food Coloring Agents
adipokines

Keywords

  • Capsanthin
  • Hepatic steatosis
  • High-fat diet
  • Lipid accumulation
  • Red paprika

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice",
abstract = "Red paprika (Capsicum annuum L.) is a widely used natural food colorant and source of vital micronutrients. The main carotenoid in red paprika is capsanthin. In this study, the effects of red paprika and capsanthin on impaired lipid metabolism were investigated in diet-induced obese mice. Forty male mice were divided into 4 groups; normal diet (ND), high-fat diet (HD), HD with red paprika, and HD with capsanthin. After 8 weeks, the red paprika and capsanthin groups showed significantly reduced weight gain, and ameliorated hypertrophy of the liver and adipose tissues. Red paprika and capsanthin treatment also improved serum lipid profile and adipokine secretion, and ameliorated hepatic steatosis by suppressing hepatic lipogenesis, fatty acid oxidation, and gluconeogenesis. In epididymal adipose tissue, red paprika and capsanthin inhibited adipogenesis and decreased lipid droplet size. Taken together, red paprika and capsanthin could ameliorate the detrimental effects of diet-induced obesity by improving impaired lipid metabolism.",
keywords = "Capsanthin, Hepatic steatosis, High-fat diet, Lipid accumulation, Red paprika",
author = "Kim, {Ji Sun} and Ha, {Tae Youl} and Suna Kim and Sung-Joon Lee and Jiyun Ahn",
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T1 - Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice

AU - Kim, Ji Sun

AU - Ha, Tae Youl

AU - Kim, Suna

AU - Lee, Sung-Joon

AU - Ahn, Jiyun

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Red paprika (Capsicum annuum L.) is a widely used natural food colorant and source of vital micronutrients. The main carotenoid in red paprika is capsanthin. In this study, the effects of red paprika and capsanthin on impaired lipid metabolism were investigated in diet-induced obese mice. Forty male mice were divided into 4 groups; normal diet (ND), high-fat diet (HD), HD with red paprika, and HD with capsanthin. After 8 weeks, the red paprika and capsanthin groups showed significantly reduced weight gain, and ameliorated hypertrophy of the liver and adipose tissues. Red paprika and capsanthin treatment also improved serum lipid profile and adipokine secretion, and ameliorated hepatic steatosis by suppressing hepatic lipogenesis, fatty acid oxidation, and gluconeogenesis. In epididymal adipose tissue, red paprika and capsanthin inhibited adipogenesis and decreased lipid droplet size. Taken together, red paprika and capsanthin could ameliorate the detrimental effects of diet-induced obesity by improving impaired lipid metabolism.

AB - Red paprika (Capsicum annuum L.) is a widely used natural food colorant and source of vital micronutrients. The main carotenoid in red paprika is capsanthin. In this study, the effects of red paprika and capsanthin on impaired lipid metabolism were investigated in diet-induced obese mice. Forty male mice were divided into 4 groups; normal diet (ND), high-fat diet (HD), HD with red paprika, and HD with capsanthin. After 8 weeks, the red paprika and capsanthin groups showed significantly reduced weight gain, and ameliorated hypertrophy of the liver and adipose tissues. Red paprika and capsanthin treatment also improved serum lipid profile and adipokine secretion, and ameliorated hepatic steatosis by suppressing hepatic lipogenesis, fatty acid oxidation, and gluconeogenesis. In epididymal adipose tissue, red paprika and capsanthin inhibited adipogenesis and decreased lipid droplet size. Taken together, red paprika and capsanthin could ameliorate the detrimental effects of diet-induced obesity by improving impaired lipid metabolism.

KW - Capsanthin

KW - Hepatic steatosis

KW - High-fat diet

KW - Lipid accumulation

KW - Red paprika

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