Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression

Giuseppe Fanelli, Francesco Benedetti, Sheng Min Wang, Soo Jung Lee, Tae Youn Jun, Prakash S. Masand, Ashwin A. Patkar, Changsu Han, Alessandro Serretti, Chi Un Pae, Chiara Fabbri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). Methods: The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment. Results: CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms. Limitations: Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels. Conclusions: This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.

Original languageEnglish
Pages (from-to)410-417
Number of pages8
JournalJournal of Affective Disorders
Volume249
DOIs
Publication statusPublished - 2019 Apr 15

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Chemokine CXCL1
Major Depressive Disorder
Biomarkers
Depression
Cytokines
Geriatrics
Linear Models
Logistic Models

Keywords

  • Biomarkers
  • Chemokines
  • Cytokine weighted score
  • Cytokines
  • Inflammation
  • Major depression

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Fanelli, G., Benedetti, F., Wang, S. M., Lee, S. J., Jun, T. Y., Masand, P. S., ... Fabbri, C. (2019). Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. Journal of Affective Disorders, 249, 410-417. https://doi.org/10.1016/j.jad.2019.02.042

Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. / Fanelli, Giuseppe; Benedetti, Francesco; Wang, Sheng Min; Lee, Soo Jung; Jun, Tae Youn; Masand, Prakash S.; Patkar, Ashwin A.; Han, Changsu; Serretti, Alessandro; Pae, Chi Un; Fabbri, Chiara.

In: Journal of Affective Disorders, Vol. 249, 15.04.2019, p. 410-417.

Research output: Contribution to journalArticle

Fanelli, G, Benedetti, F, Wang, SM, Lee, SJ, Jun, TY, Masand, PS, Patkar, AA, Han, C, Serretti, A, Pae, CU & Fabbri, C 2019, 'Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression', Journal of Affective Disorders, vol. 249, pp. 410-417. https://doi.org/10.1016/j.jad.2019.02.042
Fanelli, Giuseppe ; Benedetti, Francesco ; Wang, Sheng Min ; Lee, Soo Jung ; Jun, Tae Youn ; Masand, Prakash S. ; Patkar, Ashwin A. ; Han, Changsu ; Serretti, Alessandro ; Pae, Chi Un ; Fabbri, Chiara. / Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression. In: Journal of Affective Disorders. 2019 ; Vol. 249. pp. 410-417.
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abstract = "Background: Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). Methods: The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment. Results: CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms. Limitations: Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels. Conclusions: This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.",
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T1 - Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression

AU - Fanelli, Giuseppe

AU - Benedetti, Francesco

AU - Wang, Sheng Min

AU - Lee, Soo Jung

AU - Jun, Tae Youn

AU - Masand, Prakash S.

AU - Patkar, Ashwin A.

AU - Han, Changsu

AU - Serretti, Alessandro

AU - Pae, Chi Un

AU - Fabbri, Chiara

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Background: Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). Methods: The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment. Results: CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms. Limitations: Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels. Conclusions: This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.

AB - Background: Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). Methods: The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment. Results: CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms. Limitations: Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels. Conclusions: This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.

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KW - Chemokines

KW - Cytokine weighted score

KW - Cytokines

KW - Inflammation

KW - Major depression

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