Reduced frontal P3a amplitude in migraine patients during the pain-free period

Yong Seo Koo, Deokwon Ko, Gwan Taek Lee, Kyungmi Oh, Myung Sun Kim, Kyung Hwan Kim, Chang Hwan Im, Ki Young Jung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Purpose Neuropsychological and neuroimaging studies both suggest that frontal lobe dysfunction is present in migraineurs. Since P3a abnormalities manifest in other diseases associated with attention problems, such as attention deficit hyperactivity disorder, we hypothesized that migraine patients have P3a abnormalities, particularly in the frontal region. Methods Event-related potentials were measured using a passive auditory oddball paradigm in 16 female migraineurs (aged 22.9±2.0 years, mean±SD) during the interictal period and in 16 age-matched healthy females (22.6±2.0 years). The amplitudes and latencies were analyzed independently using repeated-measures analysis of variance. Nonparametric statistical testing using a cluster-level randomization method was performed to localize the abnormalities. Results The mean P3a amplitude at frontal areas during the third trials was significantly lower in migraineurs (1.06 μV) than in controls (1.69 μV, p=0.026). P3a amplitudes were negatively correlated with the duration of the migraine history (r=-0.618, p=0.014). Cluster-based non-parametric statistical analysis showed that the amplitudes over left frontal areas were significantly lower in migraine patients than in controls. Conclusions A reduced P3a amplitude of migraineurs reflects attentional deficits and frontal dysfunction. The negative correlation between P3a amplitude and the duration of the migraine history suggests that attentional deficits and frontal dysfunction are either the cause or the result of headache.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume9
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Migraine Disorders
Frontal Lobe
Attention Deficit Disorder with Hyperactivity
Random Allocation
Evoked Potentials
Neuroimaging
Headache
Analysis of Variance
Pain-Free

Keywords

  • Attention
  • Cognitive function
  • Event-related potentials
  • Frontal
  • Migraine
  • P3a

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Reduced frontal P3a amplitude in migraine patients during the pain-free period. / Koo, Yong Seo; Ko, Deokwon; Lee, Gwan Taek; Oh, Kyungmi; Kim, Myung Sun; Kim, Kyung Hwan; Im, Chang Hwan; Jung, Ki Young.

In: Journal of Clinical Neurology (Korea), Vol. 9, No. 1, 01.01.2013, p. 43-50.

Research output: Contribution to journalArticle

Koo, Yong Seo ; Ko, Deokwon ; Lee, Gwan Taek ; Oh, Kyungmi ; Kim, Myung Sun ; Kim, Kyung Hwan ; Im, Chang Hwan ; Jung, Ki Young. / Reduced frontal P3a amplitude in migraine patients during the pain-free period. In: Journal of Clinical Neurology (Korea). 2013 ; Vol. 9, No. 1. pp. 43-50.
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AB - Background and Purpose Neuropsychological and neuroimaging studies both suggest that frontal lobe dysfunction is present in migraineurs. Since P3a abnormalities manifest in other diseases associated with attention problems, such as attention deficit hyperactivity disorder, we hypothesized that migraine patients have P3a abnormalities, particularly in the frontal region. Methods Event-related potentials were measured using a passive auditory oddball paradigm in 16 female migraineurs (aged 22.9±2.0 years, mean±SD) during the interictal period and in 16 age-matched healthy females (22.6±2.0 years). The amplitudes and latencies were analyzed independently using repeated-measures analysis of variance. Nonparametric statistical testing using a cluster-level randomization method was performed to localize the abnormalities. Results The mean P3a amplitude at frontal areas during the third trials was significantly lower in migraineurs (1.06 μV) than in controls (1.69 μV, p=0.026). P3a amplitudes were negatively correlated with the duration of the migraine history (r=-0.618, p=0.014). Cluster-based non-parametric statistical analysis showed that the amplitudes over left frontal areas were significantly lower in migraine patients than in controls. Conclusions A reduced P3a amplitude of migraineurs reflects attentional deficits and frontal dysfunction. The negative correlation between P3a amplitude and the duration of the migraine history suggests that attentional deficits and frontal dysfunction are either the cause or the result of headache.

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