Reduced platelet BDNF level in patients with major depression

Bun Hee Lee, Yong Ku Kim

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Serum and plasma brain-derived neurotrophic factor (BDNF) levels as well as brain BDNF have previously been shown to be decreased in patients with major depressive disorder (MDD). We explored whether platelet BDNF levels, circulating stored BDNF, would be lower in MDD patients than in normal controls. BDNF levels were examined in platelet-rich plasma (PRP) and platelet-poor plasma (PPP) in 20 hospitalized non-suicidal MDD patients, 20 recent-suicidal MDD patients, and 20 normal controls. Platelet BDNF content was calculated by subtracting PPP BDNF level from PRP BDNF level, and dividing the result by the total platelet count, and it was expressed as pg/106 platelets. Individuals were evaluated using a Structured Clinical Interview for DSM-IV and a Hamilton Depression Rating Scale. Platelet BDNF contents were significantly lower in non-suicidal patients (3.09 ± 2.53 pg/106 platelets) and recent-suicidal MDD patients (3.16 ± 1.99 pg/106 platelets) than in healthy controls (6.17 ± 2.64 pg/106 platelets) (p < 0.01). However, platelet BDNF contents had no significant differences between non-suicidal and recent-suicidal patients. PRP BDNF levels were also significantly lower in non-suicidal and suicidal MDD patients than in healthy controls (p = 0.029), while PPP BDNF had no significant difference between 3 groups (p = 0.971). Our findings suggest that there is a decrease in the platelet BDNF of patients with major depression. Reduced platelet BDNF contents as circulating stored BDNF could be associated with lower serum BDNF level in patients with major depression.

Original languageEnglish
Pages (from-to)849-853
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number5
DOIs
Publication statusPublished - 2009 Aug 1

Fingerprint

Brain-Derived Neurotrophic Factor
Blood Platelets
Depression
Major Depressive Disorder
Platelet-Rich Plasma
Serum
Platelet Count
Diagnostic and Statistical Manual of Mental Disorders

Keywords

  • BDNF
  • Major depression
  • Platelet
  • Recurrence
  • Suicide

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Reduced platelet BDNF level in patients with major depression. / Lee, Bun Hee; Kim, Yong Ku.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 5, 01.08.2009, p. 849-853.

Research output: Contribution to journalArticle

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