Reduced white matter integrity in antisocial personality disorder: A diffusion tensor imaging study

Weixiong Jiang, Feng Shi, Huasheng Liu, Gang Li, Zhongxiang Ding, Hui Shen, Celina Shen, Seong Whan Lee, Dewen Hu, Wei Wang, Dinggang Shen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Emerging neuroimaging research suggests that antisocial personality disorder (ASPD) may be linked to abnormal brain anatomy, but little is known about possible impairments of white matter microstructure in ASPD, as well as their relationship with impulsivity or risky behaviors. In this study, we systematically investigated white matter abnormalities of ASPD using diffusion tensor imaging (DTI) measures: fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD). Then, we further investigated their correlations with the scores of impulsivity or risky behaviors. ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect the fronto-parietal control network and the fronto-temporal network. We also found AD/RD deficits in some additional white matter tracts that were not detected by FA. More interestingly, several regions were found correlated with impulsivity or risky behaviors in AD and RD values, although not in FA values, including the splenium of corpus callosum, left posterior corona radiate/posterior thalamic radiate, right superior longitudinal fasciculus, and left inferior longitudinal fasciculus. These regions can be the potential biomarkers, which would be of great interest in further understanding the pathomechanism of ASPD.

Original languageEnglish
Article number43002
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 2017 Feb 22

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Antisocial Personality Disorder
Diffusion Tensor Imaging
Anisotropy
Impulsive Behavior
Corpus Callosum
Neuroimaging
Anatomy
Biomarkers
White Matter
Brain
Research

ASJC Scopus subject areas

  • General

Cite this

Reduced white matter integrity in antisocial personality disorder : A diffusion tensor imaging study. / Jiang, Weixiong; Shi, Feng; Liu, Huasheng; Li, Gang; Ding, Zhongxiang; Shen, Hui; Shen, Celina; Lee, Seong Whan; Hu, Dewen; Wang, Wei; Shen, Dinggang.

In: Scientific Reports, Vol. 7, 43002, 22.02.2017.

Research output: Contribution to journalArticle

Jiang, Weixiong ; Shi, Feng ; Liu, Huasheng ; Li, Gang ; Ding, Zhongxiang ; Shen, Hui ; Shen, Celina ; Lee, Seong Whan ; Hu, Dewen ; Wang, Wei ; Shen, Dinggang. / Reduced white matter integrity in antisocial personality disorder : A diffusion tensor imaging study. In: Scientific Reports. 2017 ; Vol. 7.
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