Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice

Mak Soon Lee, In-Hwan Kim, Chong Tai Kim, Yangha Kim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This study investigated the antiobesity effect of garlic in diet-induced obese mice. Male C57BL/6J mice were fed a high-fat diet (45% fat) for 8 wk to induce obesity. Subsequently, they were fed a high-fat control diet, high-fat diets supplemented with 2%, or 5% garlic (wt:wt) for another 7 wk. Dietary garlic reduced body weight and the mass of various white adipose tissue deposits and also ameliorated the high-fat diet-induced abnormal plasma and liver lipid profiles. Garlic supplementation significantly decreased the mRNA levels of adipogenic genes in white adipose tissues (WAT). However, consumption of garlic increased the expression of mRNA for uncoupling proteins in brown adipose tissue (BAT), liver, WAT, and skeletal muscle. Mice treated with garlic maintained a significantly higher body temperature than untreated mice during a 6-h, 4°C cold challenge and, notably, AMP-activated protein kinase (AMPK) activity was stimulated in BAT, liver, WAT, and skeletal muscle. These results suggest that the antiobesity effects of garlic were at least partially mediated via activation of AMPK, increased thermogenesis, and decreased expression of multiple genes involved in adipogenesis.

Original languageEnglish
Pages (from-to)1947-1953
Number of pages7
JournalJournal of Nutrition
Volume141
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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Obese Mice
Garlic
AMP-Activated Protein Kinases
Body Weight
White Adipose Tissue
Diet
Messenger RNA
High Fat Diet
Liver
Skeletal Muscle
Adipogenesis
Brown Adipose Tissue
Thermogenesis
Mitochondrial Uncoupling Proteins
Body Temperature
Inbred C57BL Mouse
Obesity
Fats
Lipids
Gene Expression

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice. / Lee, Mak Soon; Kim, In-Hwan; Kim, Chong Tai; Kim, Yangha.

In: Journal of Nutrition, Vol. 141, No. 11, 01.11.2011, p. 1947-1953.

Research output: Contribution to journalArticle

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