Regeneration of bone defect using micro-bioceramic PLLA polymer scaffolds synthesized by nonsolvent and solvent method

Min Sung Park, Youngmee Jung, Soo Hyun Kim, Sang Heon Kim, Young Ha Kim, Byoung Goo Min, Jin Woo Lee

Research output: Contribution to journalArticle

Abstract

Poly-L-lactic acid (PLLA) is a desirable and very attractive polymer for fabricating porous scaffolds. As of now, a solvent casting method with organic solvents has been used in scaffold fabrication process. However, residual organic solvents in the scaffolds have the problems of decreasing the effect of osteogenic induction due to the hindrance of bioceramic by polymer solution and it's harmfulness in vivo. To avoid these disadvantages of scaffolds by organic solvent casting method, we developed a new method fabricating polymer (PLLA)/ceramic (β -TCP) composite scaffolds by baking method without using solvent, and then we tested properties of scaffolds on animals. As the result, non-toxicity has been proved through animal experiment and newly fabricated polymer/ceramic composites by a novel sintering method were induced rapid bone regeneration through enhancing the interaction of cells and a bone induction factor without any host immune response.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalKey Engineering Materials
Volume342-343
Publication statusPublished - 2007 Apr 16
Externally publishedYes

Fingerprint

Bioceramics
Lactic acid
Scaffolds
Polymers
Bone
Defects
Organic solvents
Casting
Animals
Composite materials
Scaffolds (biology)
Polymer solutions
Sintering
poly(lactic acid)
Fabrication
Experiments

Keywords

  • Beta-tricalcium phosphate
  • Bone regeneration
  • Mesenchymal stem cell
  • Osteogenesis
  • Poly-L-lactic-acid

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Park, M. S., Jung, Y., Kim, S. H., Kim, S. H., Kim, Y. H., Min, B. G., & Lee, J. W. (2007). Regeneration of bone defect using micro-bioceramic PLLA polymer scaffolds synthesized by nonsolvent and solvent method. Key Engineering Materials, 342-343, 145-148.

Regeneration of bone defect using micro-bioceramic PLLA polymer scaffolds synthesized by nonsolvent and solvent method. / Park, Min Sung; Jung, Youngmee; Kim, Soo Hyun; Kim, Sang Heon; Kim, Young Ha; Min, Byoung Goo; Lee, Jin Woo.

In: Key Engineering Materials, Vol. 342-343, 16.04.2007, p. 145-148.

Research output: Contribution to journalArticle

Park, MS, Jung, Y, Kim, SH, Kim, SH, Kim, YH, Min, BG & Lee, JW 2007, 'Regeneration of bone defect using micro-bioceramic PLLA polymer scaffolds synthesized by nonsolvent and solvent method', Key Engineering Materials, vol. 342-343, pp. 145-148.
Park, Min Sung ; Jung, Youngmee ; Kim, Soo Hyun ; Kim, Sang Heon ; Kim, Young Ha ; Min, Byoung Goo ; Lee, Jin Woo. / Regeneration of bone defect using micro-bioceramic PLLA polymer scaffolds synthesized by nonsolvent and solvent method. In: Key Engineering Materials. 2007 ; Vol. 342-343. pp. 145-148.
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