Regression of chemotherapy-resistant polymerase ϵ (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab

Alessandro D. Santin, Stefania Bellone, Natalia Buza, Jungmin Choi, Peter E. Schwartz, Joseph Schlessinger, Richard P. Lifton

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

Purpose: The management of endometrial carcinoma no longer amenable to treatment with surgery or radiotherapy has not improved significantly with modern chemotherapy. Alternative therapeutic options are desperately needed. Experimental Design: We describe 2 heavily pretreated patients with recurrent disease refractory to surgery, radiotherapy, and chemotherapy who were treated with the anti-PD-1 immune checkpoint inhibitor nivolumab. Results: Patient #1 harbored an ultra-mutated tumor (mutation load/MB = 117.3, total mutations = 4,660) driven by mutation in the exonuclease domain of the DNA polymerase e gene. Patient #2 harbored a hyper-mutated tumor (mutation load/MB = 33.5, total mutations = 1,037) due to a germinal MSH6 gene mutation. Both patients demonstrated a remarkable clinical response to the anti-PD-1 immune checkpoint inhibitor nivolumab. Patients' clinical responses remain unchanged at the time of the writing of this report, with no grade 3 or higher side effects reported to date. Conclusions: Anti-PD-1 inhibitors represent a novel treatment option for recurrent/metastatic, ultra/hyper-mutated human tumors refractory to salvage treatment.

Original languageEnglish
Pages (from-to)5682-5687
Number of pages6
JournalClinical Cancer Research
Volume22
Issue number23
DOIs
Publication statusPublished - 2016 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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