TY - JOUR
T1 - Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems
AU - Park, Joong Yull
AU - Takayama, Shuichi
AU - Lee, Sang Hoon
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Cells express hundreds of different types of receptors, which they use to continuously monitor their chemical and mechanical microenvironments. Stem cells and cancer cells are particularly sensitive to microenvironmental cues because their interactions have profound effects on stem cell potency and tumorigenesis, respectively. Unlike conventional tissue culture in wells and dishes, microtechnology with dimensions on the cellular scale can be combined with materials, chemicals, physiological flows, and other effectors to provide high levels of control in a format more flexible than macroscale in vitro or in vivo systems, revealing stimulation-specific responses of stem cells and cancer cells. Microtechnology-integrated biology enable the simultaneous control of multiple numbers of biological microenvironmental factors in a high-throughput manner. In this review we present representative examples of the use of microtechnology systems to regulate the mechanical, chemical, topological, adhesive, and other environments of individual stem cells and cancer cells. We then explore the possibilities for simultaneous multimodal control of combinations of these environmental factors.
AB - Cells express hundreds of different types of receptors, which they use to continuously monitor their chemical and mechanical microenvironments. Stem cells and cancer cells are particularly sensitive to microenvironmental cues because their interactions have profound effects on stem cell potency and tumorigenesis, respectively. Unlike conventional tissue culture in wells and dishes, microtechnology with dimensions on the cellular scale can be combined with materials, chemicals, physiological flows, and other effectors to provide high levels of control in a format more flexible than macroscale in vitro or in vivo systems, revealing stimulation-specific responses of stem cells and cancer cells. Microtechnology-integrated biology enable the simultaneous control of multiple numbers of biological microenvironmental factors in a high-throughput manner. In this review we present representative examples of the use of microtechnology systems to regulate the mechanical, chemical, topological, adhesive, and other environments of individual stem cells and cancer cells. We then explore the possibilities for simultaneous multimodal control of combinations of these environmental factors.
UR - http://www.scopus.com/inward/record.url?scp=77953353983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953353983&partnerID=8YFLogxK
U2 - 10.1039/c000442a
DO - 10.1039/c000442a
M3 - Review article
C2 - 20535416
AN - SCOPUS:77953353983
VL - 2
SP - 229
EP - 240
JO - Integrative biology : quantitative biosciences from nano to macro
JF - Integrative biology : quantitative biosciences from nano to macro
SN - 1757-9694
IS - 5-6
ER -