Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells

Tae Woo Jung, Myung Won Lee, Yong Jik Lee, Seon Mee Kim, Kyoung Tae Lee, Wan Kyunn Whang, Hwan Ju Cheon, Yeon Taek Jeong, Kun Wook Chung, Jae Min Cho, Do Hoon Kim

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-α.

    Original languageEnglish
    Pages (from-to)377-382
    Number of pages6
    JournalEndocrine Journal
    Volume56
    Issue number3
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Adiponectin receptor 2
    • Clofibrate
    • Palmitate
    • Peroxisome proliferator-activated receptor-alpha
    • β cells

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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