Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells

Tae Woo Jung, Myung Won Lee, Yong Jik Lee, Seon Mee Kim, Kyoung Tae Lee, Wan Kyunn Whang, Hwan Ju Cheon, Yeon Taek Jeong, Kun Wook Chung, Jae Min Cho, Do Hoon Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-α.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalEndocrine Journal
Volume56
Issue number3
DOIs
Publication statusPublished - 2009 Jul 20

Fingerprint

Adiponectin Receptors
PPAR alpha
Palmitates
Clofibrate
Adiponectin
Hypoglycemic Agents
Adipocytes
Small Interfering RNA
Diabetes Mellitus
Muscles
Liver

Keywords

  • β cells
  • Adiponectin receptor 2
  • Clofibrate
  • Palmitate
  • Peroxisome proliferator-activated receptor-alpha

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Jung, T. W., Lee, M. W., Lee, Y. J., Kim, S. M., Lee, K. T., Whang, W. K., ... Kim, D. H. (2009). Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells. Endocrine Journal, 56(3), 377-382. https://doi.org/10.1507/endocrj.K08E-354

Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells. / Jung, Tae Woo; Lee, Myung Won; Lee, Yong Jik; Kim, Seon Mee; Lee, Kyoung Tae; Whang, Wan Kyunn; Cheon, Hwan Ju; Jeong, Yeon Taek; Chung, Kun Wook; Cho, Jae Min; Kim, Do Hoon.

In: Endocrine Journal, Vol. 56, No. 3, 20.07.2009, p. 377-382.

Research output: Contribution to journalArticle

Jung, TW, Lee, MW, Lee, YJ, Kim, SM, Lee, KT, Whang, WK, Cheon, HJ, Jeong, YT, Chung, KW, Cho, JM & Kim, DH 2009, 'Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells', Endocrine Journal, vol. 56, no. 3, pp. 377-382. https://doi.org/10.1507/endocrj.K08E-354
Jung, Tae Woo ; Lee, Myung Won ; Lee, Yong Jik ; Kim, Seon Mee ; Lee, Kyoung Tae ; Whang, Wan Kyunn ; Cheon, Hwan Ju ; Jeong, Yeon Taek ; Chung, Kun Wook ; Cho, Jae Min ; Kim, Do Hoon. / Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells. In: Endocrine Journal. 2009 ; Vol. 56, No. 3. pp. 377-382.
@article{0639a3925bea484c9552ef46ccf9162d,
title = "Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells",
abstract = "Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-α.",
keywords = "β cells, Adiponectin receptor 2, Clofibrate, Palmitate, Peroxisome proliferator-activated receptor-alpha",
author = "Jung, {Tae Woo} and Lee, {Myung Won} and Lee, {Yong Jik} and Kim, {Seon Mee} and Lee, {Kyoung Tae} and Whang, {Wan Kyunn} and Cheon, {Hwan Ju} and Jeong, {Yeon Taek} and Chung, {Kun Wook} and Cho, {Jae Min} and Kim, {Do Hoon}",
year = "2009",
month = "7",
day = "20",
doi = "10.1507/endocrj.K08E-354",
language = "English",
volume = "56",
pages = "377--382",
journal = "Endocrine Journal",
issn = "0918-8959",
publisher = "Japan Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Regulation of adiponectin receptor 2 expression via PPAR-α in NIT-1 cells

AU - Jung, Tae Woo

AU - Lee, Myung Won

AU - Lee, Yong Jik

AU - Kim, Seon Mee

AU - Lee, Kyoung Tae

AU - Whang, Wan Kyunn

AU - Cheon, Hwan Ju

AU - Jeong, Yeon Taek

AU - Chung, Kun Wook

AU - Cho, Jae Min

AU - Kim, Do Hoon

PY - 2009/7/20

Y1 - 2009/7/20

N2 - Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-α.

AB - Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in β cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in β cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened β cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-α) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-α; this delay was abolished by PPAR-α targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-α.

KW - β cells

KW - Adiponectin receptor 2

KW - Clofibrate

KW - Palmitate

KW - Peroxisome proliferator-activated receptor-alpha

UR - http://www.scopus.com/inward/record.url?scp=67650496962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650496962&partnerID=8YFLogxK

U2 - 10.1507/endocrj.K08E-354

DO - 10.1507/endocrj.K08E-354

M3 - Article

VL - 56

SP - 377

EP - 382

JO - Endocrine Journal

JF - Endocrine Journal

SN - 0918-8959

IS - 3

ER -