Regulation of AHI1 expression in adult rat brain: Implication in hypothalamic feeding control

Seung Baek Han, Byung il Choi, Dongmin Lee, Sun Ho Kee, Hyeon Soo Kim, Woong Sun, Hyun Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Recent studies revealed that Abelson helper integration site 1 (AHI1) plays a role in brain development. However, little is known about the role of AHI1 in adult brain. To directly assess the role of AHI1 in the adult brain, we cloned full-length cDNA of rat AHI1 and observed prominent expression of AHI1 in the hypothalamus, which contributes mainly to the control of energy homeostasis. Furthermore, we demonstrated that food deprivation caused induction of AHI1 in the hypothalamus and subsequent re-feeding down-regulated AHI1 expression, suggesting the involvement of AHI1 in feeding control. Moreover, the expression of AHI1 was increased in serum-depleted Neuro2A cells and restored by subsequent insulin treatment. Furthermore, treatment in food-deprived rat with intraperitoneal glucose also reduced the increased AHI1 expression. These results demonstrate that AHI1 expression can be regulated through diet and suggest the novel role of AHI1 in feeding behavior.

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalBiochemical and biophysical research communications
Volume390
Issue number3
DOIs
Publication statusPublished - 2009 Dec 18

Keywords

  • AHI1
  • Feeding behavior
  • Hypothalamus
  • Insulin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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