Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins

Seungnam Han, Jungyong Nam, Yan Li, Seho Kim, Suk Hee Cho, Yi Sul Cho, So Yeon Choi, Jeonghoon Choi, Kihoon Han, Youngrim Kim, Moonseok Na, Hyun Kim, Yong Chul Bae, Se Young Choi, Eunjoon Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.

Original languageEnglish
Pages (from-to)15102-15112
Number of pages11
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
Publication statusPublished - 2010 Nov 10

Fingerprint

Post-Synaptic Density
Dendritic Spines
Embryonic Development
Synapses
Proteins
Protein Interaction Domains and Motifs
Dentate Gyrus
Hippocampus
Spine
Maintenance
Neurons
Spatial Memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. / Han, Seungnam; Nam, Jungyong; Li, Yan; Kim, Seho; Cho, Suk Hee; Cho, Yi Sul; Choi, So Yeon; Choi, Jeonghoon; Han, Kihoon; Kim, Youngrim; Na, Moonseok; Kim, Hyun; Bae, Yong Chul; Choi, Se Young; Kim, Eunjoon.

In: Journal of Neuroscience, Vol. 30, No. 45, 10.11.2010, p. 15102-15112.

Research output: Contribution to journalArticle

Han, S, Nam, J, Li, Y, Kim, S, Cho, SH, Cho, YS, Choi, SY, Choi, J, Han, K, Kim, Y, Na, M, Kim, H, Bae, YC, Choi, SY & Kim, E 2010, 'Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins', Journal of Neuroscience, vol. 30, no. 45, pp. 15102-15112. https://doi.org/10.1523/JNEUROSCI.3128-10.2010
Han, Seungnam ; Nam, Jungyong ; Li, Yan ; Kim, Seho ; Cho, Suk Hee ; Cho, Yi Sul ; Choi, So Yeon ; Choi, Jeonghoon ; Han, Kihoon ; Kim, Youngrim ; Na, Moonseok ; Kim, Hyun ; Bae, Yong Chul ; Choi, Se Young ; Kim, Eunjoon. / Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 45. pp. 15102-15112.
@article{01dd6f542ab140dcbeb3681a2c9a56c2,
title = "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins",
abstract = "PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.",
author = "Seungnam Han and Jungyong Nam and Yan Li and Seho Kim and Cho, {Suk Hee} and Cho, {Yi Sul} and Choi, {So Yeon} and Jeonghoon Choi and Kihoon Han and Youngrim Kim and Moonseok Na and Hyun Kim and Bae, {Yong Chul} and Choi, {Se Young} and Eunjoon Kim",
year = "2010",
month = "11",
day = "10",
doi = "10.1523/JNEUROSCI.3128-10.2010",
language = "English",
volume = "30",
pages = "15102--15112",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",

}

TY - JOUR

T1 - Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins

AU - Han, Seungnam

AU - Nam, Jungyong

AU - Li, Yan

AU - Kim, Seho

AU - Cho, Suk Hee

AU - Cho, Yi Sul

AU - Choi, So Yeon

AU - Choi, Jeonghoon

AU - Han, Kihoon

AU - Kim, Youngrim

AU - Na, Moonseok

AU - Kim, Hyun

AU - Bae, Yong Chul

AU - Choi, Se Young

AU - Kim, Eunjoon

PY - 2010/11/10

Y1 - 2010/11/10

N2 - PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.

AB - PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.

UR - http://www.scopus.com/inward/record.url?scp=78149481207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149481207&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.3128-10.2010

DO - 10.1523/JNEUROSCI.3128-10.2010

M3 - Article

VL - 30

SP - 15102

EP - 15112

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 45

ER -