Regulation of IL-18 expression by CRH in mouse microglial cells

Yoolhee Yang, Eunsil Hahm, Youngin Kim, Jaeseung Kang, Wangjae Lee, Innoc Han, Pyungkeun Myung, Hyungsik Kang, Hyunjeong Park, Daeho Cho

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalImmunology Letters
Volume98
Issue number2
DOIs
Publication statusPublished - 2005 May 15
Externally publishedYes

Keywords

  • BV2
  • CRH
  • IL-18
  • Microglia
  • ROI

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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