Regulation of IL-18 expression by CRH in mouse microglial cells

Yoolhee Yang, Eunsil Hahm, Youngin Kim, Jaeseung Kang, Wangjae Lee, Innoc Han, Pyungkeun Myung, Hyungsik Kang, Hyunjeong Park, Dae Ho Cho

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-l-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalImmunology Letters
Volume98
Issue number2
DOIs
Publication statusPublished - 2005 May 15
Externally publishedYes

Fingerprint

Interleukin-18
Corticotropin-Releasing Hormone
Oxygen
Microglia
Brain
Proteins

Keywords

  • BV2
  • CRH
  • IL-18
  • Microglia
  • ROI

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Regulation of IL-18 expression by CRH in mouse microglial cells. / Yang, Yoolhee; Hahm, Eunsil; Kim, Youngin; Kang, Jaeseung; Lee, Wangjae; Han, Innoc; Myung, Pyungkeun; Kang, Hyungsik; Park, Hyunjeong; Cho, Dae Ho.

In: Immunology Letters, Vol. 98, No. 2, 15.05.2005, p. 291-296.

Research output: Contribution to journalArticle

Yang, Y, Hahm, E, Kim, Y, Kang, J, Lee, W, Han, I, Myung, P, Kang, H, Park, H & Cho, DH 2005, 'Regulation of IL-18 expression by CRH in mouse microglial cells', Immunology Letters, vol. 98, no. 2, pp. 291-296. https://doi.org/10.1016/j.imlet.2004.12.003
Yang, Yoolhee ; Hahm, Eunsil ; Kim, Youngin ; Kang, Jaeseung ; Lee, Wangjae ; Han, Innoc ; Myung, Pyungkeun ; Kang, Hyungsik ; Park, Hyunjeong ; Cho, Dae Ho. / Regulation of IL-18 expression by CRH in mouse microglial cells. In: Immunology Letters. 2005 ; Vol. 98, No. 2. pp. 291-296.
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