Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice

Sergey V. Novoselov, Hwa Young Kim, Deame Hua, Byung Cheon Lee, Clinton M. Astle, David E. Harrison, Bertrand Friguet, Mohamed E. Moustafa, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the proteins that are most easily regulated by dietary selenium. MsrB1, but not MsrA activities, were reduced with age, and the selenium regulation of MsrB1 was preserved in the aging liver, suggesting that MsrB1 could account for the impaired methionine sulfoxide reduction in aging animals. We also examined regulation of Msr and selenoprotein expression by a combination of dietary selenium and calorie restriction and found that, under calorie restriction conditions, selenium regulation was preserved. In addition, mice overexpressing a mutant form of selenocysteine tRNA reduced MsrB1 activity to the level observed in selenium deficiency, whereas MsrA activity was elevated in these animals. Finally, we show that selenium regulation in inbred mouse strains is preserved in an outbred aging model. Taken together, these findings better define dietary regulation of methionine sulfoxide reduction and selenoprotein expression in mice with regard to age, calorie restriction, dietary Se, and a combination of these factors.

Original languageEnglish
Pages (from-to)829-838
Number of pages10
JournalAntioxidants and Redox Signaling
Volume12
Issue number7
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

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Methionine Sulfoxide Reductases
Selenoproteins
Selenium
Aging of materials
Liver
Animals
Inbred Strains Mice
Mammals
Methionine
Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. / Novoselov, Sergey V.; Kim, Hwa Young; Hua, Deame; Lee, Byung Cheon; Astle, Clinton M.; Harrison, David E.; Friguet, Bertrand; Moustafa, Mohamed E.; Carlson, Bradley A.; Hatfield, Dolph L.; Gladyshev, Vadim N.

In: Antioxidants and Redox Signaling, Vol. 12, No. 7, 01.04.2010, p. 829-838.

Research output: Contribution to journalArticle

Novoselov, SV, Kim, HY, Hua, D, Lee, BC, Astle, CM, Harrison, DE, Friguet, B, Moustafa, ME, Carlson, BA, Hatfield, DL & Gladyshev, VN 2010, 'Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice', Antioxidants and Redox Signaling, vol. 12, no. 7, pp. 829-838. https://doi.org/10.1089/ars.2009.2895
Novoselov, Sergey V. ; Kim, Hwa Young ; Hua, Deame ; Lee, Byung Cheon ; Astle, Clinton M. ; Harrison, David E. ; Friguet, Bertrand ; Moustafa, Mohamed E. ; Carlson, Bradley A. ; Hatfield, Dolph L. ; Gladyshev, Vadim N. / Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. In: Antioxidants and Redox Signaling. 2010 ; Vol. 12, No. 7. pp. 829-838.
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