Relation between ligament of marshall and adrenergic atrial tachyarrhythmia

Rahul N. Doshi, Tsu Juey Wu, Masaaki Yashima, Young Hoon Kim, James J.C. Ong, Ji Min Cao, Chun Hwang, Payam Yashar, Michael C. Fishbein, Hrayr S. Karagueuzian, Peng Sheng Chen

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Background - The mechanism of the adrenergic atrial tachyarrhythmia is unclear. We hypothesize that the ligament of Marshall (LOM) is sensitive to adrenergic stimulation and may serve as a source of the adrenergic atrial tachyarrhythmia. Methods and Results - We performed computerized mapping studies in isolated-perfused canine left atrial tissues from normal dogs (n=9) and from dogs with chronic atrial fibrillation (AF) induced by 10 to 41 weeks of rapid pacing (n=3). Before isoproterenol, spontaneous activity occurred in only one normal tissue (cycle length, CL >1300 ms). During isoproterenol infusion, automatic rhythm was induced in both normal tissues (CL=578±172 ms) and AF tissues (CL=255±29 ms, P<0.05). The origin of spontaneous activity was mapped to the LOM. In the AF tissues, but not the normal tissues, we observed the transition from rapid automatic activity to multiple wavelet AF. Ablation of the LOM terminated the spontaneous activity and prevented AF. Immunocytochemical studies of the LOM revealed muscle tracts surrounded by tyrosine hydroxylase-positive (sympathetic) nerves. Conclusions - We conclude that the LOM is richly innervated by sympathetic nerves and serves as a source of isoproterenol-sensitive focal automatic activity in normal canine atrium. The sensitivity to isoproterenol is upregulated after long-term rapid pacing and may contribute to the development of AF in this model.

Original languageEnglish
Pages (from-to)876-883
Number of pages8
JournalCirculation
Volume100
Issue number8
DOIs
Publication statusPublished - 1999 Aug 24
Externally publishedYes

Fingerprint

Ligaments
Tachycardia
Adrenergic Agents
Atrial Fibrillation
Isoproterenol
Canidae
Dogs
Tyrosine 3-Monooxygenase
carbosulfan
Muscles

Keywords

  • Atrial fibrillation
  • Catecholamines
  • Mapping
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Doshi, R. N., Wu, T. J., Yashima, M., Kim, Y. H., Ong, J. J. C., Cao, J. M., ... Chen, P. S. (1999). Relation between ligament of marshall and adrenergic atrial tachyarrhythmia. Circulation, 100(8), 876-883. https://doi.org/10.1161/01.CIR.100.8.876

Relation between ligament of marshall and adrenergic atrial tachyarrhythmia. / Doshi, Rahul N.; Wu, Tsu Juey; Yashima, Masaaki; Kim, Young Hoon; Ong, James J.C.; Cao, Ji Min; Hwang, Chun; Yashar, Payam; Fishbein, Michael C.; Karagueuzian, Hrayr S.; Chen, Peng Sheng.

In: Circulation, Vol. 100, No. 8, 24.08.1999, p. 876-883.

Research output: Contribution to journalArticle

Doshi, RN, Wu, TJ, Yashima, M, Kim, YH, Ong, JJC, Cao, JM, Hwang, C, Yashar, P, Fishbein, MC, Karagueuzian, HS & Chen, PS 1999, 'Relation between ligament of marshall and adrenergic atrial tachyarrhythmia', Circulation, vol. 100, no. 8, pp. 876-883. https://doi.org/10.1161/01.CIR.100.8.876
Doshi, Rahul N. ; Wu, Tsu Juey ; Yashima, Masaaki ; Kim, Young Hoon ; Ong, James J.C. ; Cao, Ji Min ; Hwang, Chun ; Yashar, Payam ; Fishbein, Michael C. ; Karagueuzian, Hrayr S. ; Chen, Peng Sheng. / Relation between ligament of marshall and adrenergic atrial tachyarrhythmia. In: Circulation. 1999 ; Vol. 100, No. 8. pp. 876-883.
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AU - Ong, James J.C.

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AU - Hwang, Chun

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