Relation of coronary atherosclerosis and metabolic syndrome in asymptomatic subjects: Evaluation with coronary CT angiography

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Abstract

To assess the relationship between metabolic syndrome (MetS) and coronary atherosclerosis using coronary CT angiography (CCTA) as the evaluation tool in asymptomatic cardiovascular disease (CVD) free subjects. The presence and extent of coronary atherosclerosis in 755 asymptomatic self-referred subjects were measured using CCTA. The relationships between coronary atherosclerosis, MetS, and other clinical factors were assessed. To further investigate the relationship between MetS and the presence and extent of coronary plaque, subjects were divided into 3 subgroups according to the number of metabolic factors (MF0, 1-2 or C3) and the number of coronary segments with plaque (segment involvement score: SIS0, 1, C2). MetS showed significant association with the presence of coronary plaque after adjustment for other clinical factors [odds radio (OR) 1.791 (1.159- 2.775), P = 0.009]. Among metabolic components, abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque [OR 1.708 (1.189-2.455), P = 0.004; OR 1.677 (1.165-2.415), P = 0.005]. Coronary plaque was more frequently found in subgroups with a higher number of metabolic factors (32.4, 36.7 and 52.1 %). Higher SISs were also found in subjects with more MetS components (SIS1: 14.6, 16.2 and 27.2 %; SIS C 2: 17, 19.7 and 23.7 %). In asymptomatic CVD free subjects, MetS and number of metabolic factors were related with an increased risk of the presence and the extent of coronary plaque. Abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalInternational Journal of Cardiovascular Imaging
Volume29
Issue number2 SUPPL.
DOIs
Publication statusPublished - 2013 Nov 6

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Coronary Angiography
Coronary Artery Disease
Radio
Asymptomatic Diseases
Abdominal Obesity
Cardiovascular Diseases
Hypertension
Computed Tomography Angiography

Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Coronary CT angiography
  • Metabolic syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Relation of coronary atherosclerosis and metabolic syndrome in asymptomatic subjects: Evaluation with coronary CT angiography",
abstract = "To assess the relationship between metabolic syndrome (MetS) and coronary atherosclerosis using coronary CT angiography (CCTA) as the evaluation tool in asymptomatic cardiovascular disease (CVD) free subjects. The presence and extent of coronary atherosclerosis in 755 asymptomatic self-referred subjects were measured using CCTA. The relationships between coronary atherosclerosis, MetS, and other clinical factors were assessed. To further investigate the relationship between MetS and the presence and extent of coronary plaque, subjects were divided into 3 subgroups according to the number of metabolic factors (MF0, 1-2 or C3) and the number of coronary segments with plaque (segment involvement score: SIS0, 1, C2). MetS showed significant association with the presence of coronary plaque after adjustment for other clinical factors [odds radio (OR) 1.791 (1.159- 2.775), P = 0.009]. Among metabolic components, abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque [OR 1.708 (1.189-2.455), P = 0.004; OR 1.677 (1.165-2.415), P = 0.005]. Coronary plaque was more frequently found in subgroups with a higher number of metabolic factors (32.4, 36.7 and 52.1 {\%}). Higher SISs were also found in subjects with more MetS components (SIS1: 14.6, 16.2 and 27.2 {\%}; SIS C 2: 17, 19.7 and 23.7 {\%}). In asymptomatic CVD free subjects, MetS and number of metabolic factors were related with an increased risk of the presence and the extent of coronary plaque. Abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque.",
keywords = "Atherosclerosis, Coronary artery disease, Coronary CT angiography, Metabolic syndrome",
author = "Jaeil Ryu and Hwan-Seok Yong and Sik Huh and Eun-Young Kang and Woo, {Ok Hee}",
year = "2013",
month = "11",
day = "6",
doi = "10.1007/s10554-013-0319-2",
language = "English",
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journal = "International Journal of Cardiovascular Imaging",
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TY - JOUR

T1 - Relation of coronary atherosclerosis and metabolic syndrome in asymptomatic subjects

T2 - Evaluation with coronary CT angiography

AU - Ryu, Jaeil

AU - Yong, Hwan-Seok

AU - Huh, Sik

AU - Kang, Eun-Young

AU - Woo, Ok Hee

PY - 2013/11/6

Y1 - 2013/11/6

N2 - To assess the relationship between metabolic syndrome (MetS) and coronary atherosclerosis using coronary CT angiography (CCTA) as the evaluation tool in asymptomatic cardiovascular disease (CVD) free subjects. The presence and extent of coronary atherosclerosis in 755 asymptomatic self-referred subjects were measured using CCTA. The relationships between coronary atherosclerosis, MetS, and other clinical factors were assessed. To further investigate the relationship between MetS and the presence and extent of coronary plaque, subjects were divided into 3 subgroups according to the number of metabolic factors (MF0, 1-2 or C3) and the number of coronary segments with plaque (segment involvement score: SIS0, 1, C2). MetS showed significant association with the presence of coronary plaque after adjustment for other clinical factors [odds radio (OR) 1.791 (1.159- 2.775), P = 0.009]. Among metabolic components, abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque [OR 1.708 (1.189-2.455), P = 0.004; OR 1.677 (1.165-2.415), P = 0.005]. Coronary plaque was more frequently found in subgroups with a higher number of metabolic factors (32.4, 36.7 and 52.1 %). Higher SISs were also found in subjects with more MetS components (SIS1: 14.6, 16.2 and 27.2 %; SIS C 2: 17, 19.7 and 23.7 %). In asymptomatic CVD free subjects, MetS and number of metabolic factors were related with an increased risk of the presence and the extent of coronary plaque. Abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque.

AB - To assess the relationship between metabolic syndrome (MetS) and coronary atherosclerosis using coronary CT angiography (CCTA) as the evaluation tool in asymptomatic cardiovascular disease (CVD) free subjects. The presence and extent of coronary atherosclerosis in 755 asymptomatic self-referred subjects were measured using CCTA. The relationships between coronary atherosclerosis, MetS, and other clinical factors were assessed. To further investigate the relationship between MetS and the presence and extent of coronary plaque, subjects were divided into 3 subgroups according to the number of metabolic factors (MF0, 1-2 or C3) and the number of coronary segments with plaque (segment involvement score: SIS0, 1, C2). MetS showed significant association with the presence of coronary plaque after adjustment for other clinical factors [odds radio (OR) 1.791 (1.159- 2.775), P = 0.009]. Among metabolic components, abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque [OR 1.708 (1.189-2.455), P = 0.004; OR 1.677 (1.165-2.415), P = 0.005]. Coronary plaque was more frequently found in subgroups with a higher number of metabolic factors (32.4, 36.7 and 52.1 %). Higher SISs were also found in subjects with more MetS components (SIS1: 14.6, 16.2 and 27.2 %; SIS C 2: 17, 19.7 and 23.7 %). In asymptomatic CVD free subjects, MetS and number of metabolic factors were related with an increased risk of the presence and the extent of coronary plaque. Abdominal obesity and high blood pressure were significantly associated with the presence of coronary plaque.

KW - Atherosclerosis

KW - Coronary artery disease

KW - Coronary CT angiography

KW - Metabolic syndrome

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U2 - 10.1007/s10554-013-0319-2

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EP - 107

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 2 SUPPL.

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