Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting

Young Joon Hong, Myung Ho Jeong, Sang Yeob Lim, Sang Rok Lee, Seo Na Hong, Kye Hun Kim, Il Suk Sohn, Hyung Wook Park, Ju Han Kim, Weon Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

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Abstract

Although various predictors relating to in-stent restenosis (ISR) have been demonstrated, the relation between the parameters of intravascular ultrasound and inflammatory markers and ISR has not been reported. This study included 120 patients who underwent stent implantation for angiographically significant stenosis. Patients were divided into a soft plaque group (n = 50) and a nonsoft plaque group (n = 70). All patients underwent angiographic and intravascular ultrasound follow-up at 6 months. The baseline high-sensitivity C-reactive protein (hs-CRP) level was significantly higher in the soft plaque group. The follow-up minimal lumen diameter was significantly smaller in the soft plaque group. Soft plaque was detected in 73% of the ISR group but only 27% of the non-ISR group. Also, ISR was observed in 44% of the soft plaque group in contrast to only 11% of the nonsoft plaque group. The neointimal area at the minimal lumen cross-sectional area at follow-up was significantly larger in the soft plaque group (3.7 ± 1.5 vs 1.9 ± 1.5 mm2, p <0.001). In conclusion, in patients with soft plaque, an elevated hs-CRP level was significantly associated with ISR (63% vs 15%, p <0.001). By multivariate analysis, the combination of soft plaque and elevated hs-CRP was the most significant independent predictor of ISR.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalAmerican Journal of Cardiology
Volume98
Issue number3
DOIs
Publication statusPublished - 2006 Aug 1
Externally publishedYes

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C-Reactive Protein
Stents
Coronary Vessels
Incidence
Pathologic Constriction
Multivariate Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting. / Hong, Young Joon; Jeong, Myung Ho; Lim, Sang Yeob; Lee, Sang Rok; Hong, Seo Na; Kim, Kye Hun; Sohn, Il Suk; Park, Hyung Wook; Kim, Ju Han; Kim, Weon; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee.

In: American Journal of Cardiology, Vol. 98, No. 3, 01.08.2006, p. 341-345.

Research output: Contribution to journalArticle

Hong, Young Joon ; Jeong, Myung Ho ; Lim, Sang Yeob ; Lee, Sang Rok ; Hong, Seo Na ; Kim, Kye Hun ; Sohn, Il Suk ; Park, Hyung Wook ; Kim, Ju Han ; Kim, Weon ; Ahn, Youngkeun ; Cho, Jeong Gwan ; Park, Jong Chun ; Kang, Jung Chaee. / Relation of Soft Plaque and Elevated Preprocedural High-Sensitivity C-Reactive Protein Levels to Incidence of In-Stent Restenosis After Successful Coronary Artery Stenting. In: American Journal of Cardiology. 2006 ; Vol. 98, No. 3. pp. 341-345.
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abstract = "Although various predictors relating to in-stent restenosis (ISR) have been demonstrated, the relation between the parameters of intravascular ultrasound and inflammatory markers and ISR has not been reported. This study included 120 patients who underwent stent implantation for angiographically significant stenosis. Patients were divided into a soft plaque group (n = 50) and a nonsoft plaque group (n = 70). All patients underwent angiographic and intravascular ultrasound follow-up at 6 months. The baseline high-sensitivity C-reactive protein (hs-CRP) level was significantly higher in the soft plaque group. The follow-up minimal lumen diameter was significantly smaller in the soft plaque group. Soft plaque was detected in 73{\%} of the ISR group but only 27{\%} of the non-ISR group. Also, ISR was observed in 44{\%} of the soft plaque group in contrast to only 11{\%} of the nonsoft plaque group. The neointimal area at the minimal lumen cross-sectional area at follow-up was significantly larger in the soft plaque group (3.7 ± 1.5 vs 1.9 ± 1.5 mm2, p <0.001). In conclusion, in patients with soft plaque, an elevated hs-CRP level was significantly associated with ISR (63{\%} vs 15{\%}, p <0.001). By multivariate analysis, the combination of soft plaque and elevated hs-CRP was the most significant independent predictor of ISR.",
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