Relationship Between Bariatric Surgery and Bone Mineral Density: a Meta-analysis

Byung Joon Ko, Seung Kwon Myung, Kyung-Hwan Cho, Yong Gyu Park, Sin Gon Kim, Do-Hoon Kim, Seon Mee Kim

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Background: A meta-analysis regarding bone loss after bariatric surgery, designed to compare surgical and nonsurgical groups, has not yet been performed. Therefore, we performed a meta-analysis to compare the differences between bariatric surgical groups and nonoperated controls with regard to bone mineral density. Methods: In March 2015, we performed a review of the literature using PubMed, EMBASE, and the Cochrane Library. The search focused on retrospective and prospective studies, including but not limited to randomized studies published in English. Results: Among 1299 studies that were initially screened, ten met the selection criteria. For all types of bariatric surgery, bone density at the femoral neck was lower in the surgical group than in the nonsurgical control group (mean difference [MD] −0.05 g/cm2; 95 % confidence interval [CI], −0.07 to −0.02; p = 0.001); no difference in bone density was found between the two groups at the lumbar spine (MD −0.01 g/cm2; 95 % CI −0.07 to 0.05; p = 0.661). The analysis of Roux-en-Y gastric bypass showed similar results. Conclusion: Bone density at the femoral neck decreased after bariatric surgery, compared to that in nonsurgical controls, whereas bone density at the lumbar spine did not show a difference between groups. Further larger scale studies with comparative nonsurgical controls are warranted to overcome the heterogeneity among studies in this analysis and to add evidence of possible bone loss subsequent to bariatric surgical procedures.

Original languageEnglish
Pages (from-to)1414-1421
Number of pages8
JournalObesity Surgery
Volume26
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Bariatric Surgery
Bone Density
Meta-Analysis
Femur Neck
Spine
Confidence Intervals
Bariatrics
Bone and Bones
Control Groups
Gastric Bypass
PubMed
Patient Selection
Libraries
Retrospective Studies
Prospective Studies

Keywords

  • Bariatric surgery
  • Bone density
  • DXA
  • Meta-analysis

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Relationship Between Bariatric Surgery and Bone Mineral Density : a Meta-analysis. / Ko, Byung Joon; Myung, Seung Kwon; Cho, Kyung-Hwan; Park, Yong Gyu; Kim, Sin Gon; Kim, Do-Hoon; Kim, Seon Mee.

In: Obesity Surgery, Vol. 26, No. 7, 01.07.2016, p. 1414-1421.

Research output: Contribution to journalReview article

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abstract = "Background: A meta-analysis regarding bone loss after bariatric surgery, designed to compare surgical and nonsurgical groups, has not yet been performed. Therefore, we performed a meta-analysis to compare the differences between bariatric surgical groups and nonoperated controls with regard to bone mineral density. Methods: In March 2015, we performed a review of the literature using PubMed, EMBASE, and the Cochrane Library. The search focused on retrospective and prospective studies, including but not limited to randomized studies published in English. Results: Among 1299 studies that were initially screened, ten met the selection criteria. For all types of bariatric surgery, bone density at the femoral neck was lower in the surgical group than in the nonsurgical control group (mean difference [MD] −0.05 g/cm2; 95 {\%} confidence interval [CI], −0.07 to −0.02; p = 0.001); no difference in bone density was found between the two groups at the lumbar spine (MD −0.01 g/cm2; 95 {\%} CI −0.07 to 0.05; p = 0.661). The analysis of Roux-en-Y gastric bypass showed similar results. Conclusion: Bone density at the femoral neck decreased after bariatric surgery, compared to that in nonsurgical controls, whereas bone density at the lumbar spine did not show a difference between groups. Further larger scale studies with comparative nonsurgical controls are warranted to overcome the heterogeneity among studies in this analysis and to add evidence of possible bone loss subsequent to bariatric surgical procedures.",
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N2 - Background: A meta-analysis regarding bone loss after bariatric surgery, designed to compare surgical and nonsurgical groups, has not yet been performed. Therefore, we performed a meta-analysis to compare the differences between bariatric surgical groups and nonoperated controls with regard to bone mineral density. Methods: In March 2015, we performed a review of the literature using PubMed, EMBASE, and the Cochrane Library. The search focused on retrospective and prospective studies, including but not limited to randomized studies published in English. Results: Among 1299 studies that were initially screened, ten met the selection criteria. For all types of bariatric surgery, bone density at the femoral neck was lower in the surgical group than in the nonsurgical control group (mean difference [MD] −0.05 g/cm2; 95 % confidence interval [CI], −0.07 to −0.02; p = 0.001); no difference in bone density was found between the two groups at the lumbar spine (MD −0.01 g/cm2; 95 % CI −0.07 to 0.05; p = 0.661). The analysis of Roux-en-Y gastric bypass showed similar results. Conclusion: Bone density at the femoral neck decreased after bariatric surgery, compared to that in nonsurgical controls, whereas bone density at the lumbar spine did not show a difference between groups. Further larger scale studies with comparative nonsurgical controls are warranted to overcome the heterogeneity among studies in this analysis and to add evidence of possible bone loss subsequent to bariatric surgical procedures.

AB - Background: A meta-analysis regarding bone loss after bariatric surgery, designed to compare surgical and nonsurgical groups, has not yet been performed. Therefore, we performed a meta-analysis to compare the differences between bariatric surgical groups and nonoperated controls with regard to bone mineral density. Methods: In March 2015, we performed a review of the literature using PubMed, EMBASE, and the Cochrane Library. The search focused on retrospective and prospective studies, including but not limited to randomized studies published in English. Results: Among 1299 studies that were initially screened, ten met the selection criteria. For all types of bariatric surgery, bone density at the femoral neck was lower in the surgical group than in the nonsurgical control group (mean difference [MD] −0.05 g/cm2; 95 % confidence interval [CI], −0.07 to −0.02; p = 0.001); no difference in bone density was found between the two groups at the lumbar spine (MD −0.01 g/cm2; 95 % CI −0.07 to 0.05; p = 0.661). The analysis of Roux-en-Y gastric bypass showed similar results. Conclusion: Bone density at the femoral neck decreased after bariatric surgery, compared to that in nonsurgical controls, whereas bone density at the lumbar spine did not show a difference between groups. Further larger scale studies with comparative nonsurgical controls are warranted to overcome the heterogeneity among studies in this analysis and to add evidence of possible bone loss subsequent to bariatric surgical procedures.

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