Relationship between dementia and ankylosing spondylitis

A nationwide, population-based, retrospective longitudinal cohort study

Hae Dong Jang, Jin Sung Park, Dae Woong Kim, Kyungdo Han, Byung Joon Shin, Jae Chul Lee, Sung Woo Choi, Seung-Woo Suh, Jae Hyuk Yang, Si Young Park, Whi Je Cho, Jae-Young Hong

Research output: Contribution to journalArticle

Abstract

Among a variety of comorbidities of ankylosing spondylitis (AS), the association between dementia and AS by using an extensive dataset from the Korean National Health Insurance System was evaluated in this study. We extracted 15,547 newly diagnosed AS subjects among the entire Korean population and excluded wash-out patients (n = 162) and patients that were inappropriate for cohort match (n = 1192). Finally, 14,193 subjects were chosen as the AS group, and through 1:5 age- and sex-stratified matching, 70,965 subjects were chosen as the control group. We evaluated patient demographics, household incomes, and comorbidities, including hypertension, diabetes, and dyslipidemia. The prevalence of overall dementia (1.37%) and Alzheimer’s dementia (AD) (0.99%) in the AS group was significantly higher than in the control group (0.87% and 0.63%), respectively. The adjusted hazard ratio of the AS group for overall dementia (1.758) and AD (1.782) showed statistical significance also. On the other hand, the prevalence of vascular dementia did not differ significantly between the two groups. Subgroup analyses revealed the following risk factors for dementia in the AS group: male gender, greater than 65 years in age, fair income (household income greater than 20% of the median), urban residency, no diabetes, and no hypertension. From the nationwide, population-based, retrospective, longitudinal cohort study, AS patients showed a significantly higher prevalence of overall dementia and Alzheimer’s dementia. Comprehensive patient assessment using our subgroup analysis could help to prevent dementia in patients suffering from AS.

Original languageEnglish
Article numbere0210335
JournalPLoS One
Volume14
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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dementia
Ankylosing Spondylitis
Medical problems
cohort studies
Longitudinal Studies
Dementia
Cohort Studies
Health insurance
Population
Hazards
Alzheimer Disease
household income
Comorbidity
hypertension
diabetes
Hypertension
Control Groups
Vascular Dementia
health insurance
National Health Programs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Relationship between dementia and ankylosing spondylitis : A nationwide, population-based, retrospective longitudinal cohort study. / Jang, Hae Dong; Park, Jin Sung; Kim, Dae Woong; Han, Kyungdo; Shin, Byung Joon; Lee, Jae Chul; Choi, Sung Woo; Suh, Seung-Woo; Yang, Jae Hyuk; Park, Si Young; Cho, Whi Je; Hong, Jae-Young.

In: PLoS One, Vol. 14, No. 1, e0210335, 01.01.2019.

Research output: Contribution to journalArticle

Jang, Hae Dong ; Park, Jin Sung ; Kim, Dae Woong ; Han, Kyungdo ; Shin, Byung Joon ; Lee, Jae Chul ; Choi, Sung Woo ; Suh, Seung-Woo ; Yang, Jae Hyuk ; Park, Si Young ; Cho, Whi Je ; Hong, Jae-Young. / Relationship between dementia and ankylosing spondylitis : A nationwide, population-based, retrospective longitudinal cohort study. In: PLoS One. 2019 ; Vol. 14, No. 1.
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