Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients

Hye Kyung Chung, Oh Yoen Kim, Hyeran Lee, Hyun Joo Do, Young Soon Kim, Jaewon Oh, Seok Min Kang, Min-Jeong Shin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study aimed to axamine the association of dietary vitamin intakes with plasma pro-inflammatory cytokine levels in Korean heart failure patients. Stable outpatients with heart failure were recruited and finally 91 patients were included. Dietary intakes were estimated by a developed semi-quantitative food frequency questionnaire. The simultaneous measurement of 17 cytokines was performed along with analysis of plasma C-reactive protein. Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C (r = -0.30, p<0.005), β-carotene (r = -0.23, p<0.05), and folate (r = -0.31, p<0.005). However, these associations were no longer significant after adjusting for traditional risk factors for heart failure. On the other hand, plasma levels of monocyte chemoattractant protein-1 significantly correlated with dietary folate intake (r = -0.31, p<0.001), and plasma interleukin-8 levels significantly correlated with dietary intakes of vitamin C (r = -0.38, p<0.001), β-carotene (r = -0.42, p<0.001), and folate (r = -0.38, p<0.001) after the adjustment. Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p<0.005, R2 = 0.20) and interleukin-8 (p<0.001, R2 = 0.32) through a stepwise multiple linear regression analysis. Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalJournal of Clinical Biochemistry and Nutrition
Volume49
Issue number1
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Chemokine CCL2
Interleukin-8
Folic Acid
Blood Proteins
Heart Failure
Plasmas
Carotenoids
C-Reactive Protein
Ascorbic Acid
Cytokines
Treatment Failure
Vitamins
Linear Models
Linear regression
Regression analysis
Outpatients
Regression Analysis
Food

Keywords

  • Dietary folate
  • Heart failure
  • Inflammation
  • Interleukin-8
  • MCP-1

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients. / Chung, Hye Kyung; Kim, Oh Yoen; Lee, Hyeran; Do, Hyun Joo; Kim, Young Soon; Oh, Jaewon; Kang, Seok Min; Shin, Min-Jeong.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 49, No. 1, 01.07.2011, p. 62-66.

Research output: Contribution to journalArticle

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