Abstract
It has recently been reported that the mechanical behavior of prion nanofibrils may play a critical role in expression of neurodegenerative diseases. In this work, we have studied the mechanical behavior of HET-s prion nanofibrils using an elastic network model. We have shown that the mechanical properties of prion nanofibrils formed as left-handed β-helices are different from those of non-prion nanofibrils formed as right-handed β-helices. In particular, the bending behavior of prion nanofibrils depends on the length of the nanofibril and that the bending rigidity of the prion nanofibril is larger than that of the non-prion nanofibril.
Original language | English |
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Article number | 011914 |
Journal | Applied Physics Letters |
Volume | 102 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2013 Jan 7 |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)