Relationship between disease-specific structures of amyloid fibrils and their mechanical properties

Gwonchan Yoon, Young Kab Kim, Kilho Eom, Sungsoo Na

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22 Citations (Scopus)

Abstract

It has recently been reported that the mechanical behavior of prion nanofibrils may play a critical role in expression of neurodegenerative diseases. In this work, we have studied the mechanical behavior of HET-s prion nanofibrils using an elastic network model. We have shown that the mechanical properties of prion nanofibrils formed as left-handed β-helices are different from those of non-prion nanofibrils formed as right-handed β-helices. In particular, the bending behavior of prion nanofibrils depends on the length of the nanofibril and that the bending rigidity of the prion nanofibril is larger than that of the non-prion nanofibril.

Original languageEnglish
Article number011914
JournalApplied Physics Letters
Volume102
Issue number1
DOIs
Publication statusPublished - 2013 Jan 7

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ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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