Relationship between dyslipidemia and albuminuria in prediabetic adults: The Korea National Health and Nutrition Examination Survey 2011–2012

Ga Eun Nam, Kyungdo Han, Do Hoon Kim, Yong Gyu Park, Yeo Joon Yoon, Young Eun Kim, Sangsu Lee, Sungho Lee, Yong Kyun Roh

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    This study aimed to estimate the relationship between various lipid abnormalities and albuminuria in Korean prediabetic adults. Data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011–2012 were analyzed. The study consisted of 4,811 subjects in the normal glucose group and 3,872 in the prediabetic group. Prediabetes was defined by the fasting plasma glucose or hemoglobin A1c level. Albuminuria was defined as a urine albumin to creatinine ratio (UACR) ≥30 mg/g. Various parameters of dyslipidemia were assessed. No differences were observed in the prevalence of lipid abnormalities in prediabetic men with different values of UACR. Prediabetic women with increased urinary albumin excretion showed a significantly higher prevalence of lipid abnormalities. The proportion of mixed dyslipidemia was significantly higher in prediabetic women with albuminuria. Higher levels of total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and TC to HDL-C ratio, TG to HDL-C ratio, and LDL-C to HDL-C ratio were significantly associated with increased risk of albuminuria in prediabetic women. Conclusions: Several lipid abnormalities were significantly associated with the increased risk of albuminuria in prediabetic women. Hence, screening for lipid abnormalities may be helpful for identification of risk for albuminuria in prediabetic subjects.

    Original languageEnglish
    Pages (from-to)557-565
    Number of pages9
    JournalEndocrine
    Volume48
    Issue number2
    DOIs
    Publication statusPublished - 2015 Mar

    Keywords

    • Albuminuria
    • Dyslipidemia
    • Prediabetes
    • Urine albumin to creatinine ratio

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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