Relationship between fractal dimension and morphological features of Cephalosporium acremonium M25 in a 30-1 bioreactor culture

Jung Soo Lim, Jung Mo Kim, Jong Chae Kim, Chang Ho Kim, Dae Ryook Yang, Hyo-Ihl Chang, Seung Wook Kim

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4 Citations (Scopus)


In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to 1.85 g/l-1 at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.

Original languageEnglish
Pages (from-to)971-976
Number of pages6
JournalJournal of Microbiology and Biotechnology
Issue number5
Publication statusPublished - 2005 Oct 1



  • Cephalosporin C
  • Cephalosporium acremonium M25
  • Fractal dimension
  • Morphology
  • Specific differentiation rate

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

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