Abstract
In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to 1.85 g/l-1 at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.
| Original language | English |
|---|---|
| Pages (from-to) | 971-976 |
| Number of pages | 6 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 15 |
| Issue number | 5 |
| Publication status | Published - 2005 Oct 1 |
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Keywords
- Cephalosporin C
- Cephalosporium acremonium M25
- Fractal dimension
- Morphology
- Specific differentiation rate
ASJC Scopus subject areas
- Biotechnology
- Applied Microbiology and Biotechnology
- Microbiology
- Bioengineering
Cite this
Relationship between fractal dimension and morphological features of Cephalosporium acremonium M25 in a 30-1 bioreactor culture. / Lim, Jung Soo; Kim, Jung Mo; Kim, Jong Chae; Kim, Chang Ho; Yang, Dae Ryook; Chang, Hyo-Ihl; Kim, Seung Wook.
In: Journal of Microbiology and Biotechnology, Vol. 15, No. 5, 01.10.2005, p. 971-976.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between fractal dimension and morphological features of Cephalosporium acremonium M25 in a 30-1 bioreactor culture
AU - Lim, Jung Soo
AU - Kim, Jung Mo
AU - Kim, Jong Chae
AU - Kim, Chang Ho
AU - Yang, Dae Ryook
AU - Chang, Hyo-Ihl
AU - Kim, Seung Wook
PY - 2005/10/1
Y1 - 2005/10/1
N2 - In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to 1.85 g/l-1 at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.
AB - In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to 1.85 g/l-1 at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.
KW - Cephalosporin C
KW - Cephalosporium acremonium M25
KW - Fractal dimension
KW - Morphology
KW - Specific differentiation rate
UR - http://www.scopus.com/inward/record.url?scp=27944452681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27944452681&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:27944452681
VL - 15
SP - 971
EP - 976
JO - Journal of Microbiology and Biotechnology
JF - Journal of Microbiology and Biotechnology
SN - 1017-7825
IS - 5
ER -