Relationship between high serum ferritin level and glaucoma in a South Korean population: The Kangbuk Samsung health study

Hyo Jung Gye, Joon Mo Kim, Chungkwon Yoo, Seong Hee Shim, Yu Sam Won, Ki Chul Sung, Mi Yeon Lee, Ki Ho Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/aims To investigate the association between serum ferritin levels and glaucoma in a South Korean population. Methods This retrospective cross-sectional study included 164029 subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. All subjects underwent a physical examination, answered sociodemographic and behavioural questions, and provided samples for laboratory analyses. A digital fundus photograph of both eyes was taken, and all photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye had glaucoma based on criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and the appearance of the retinal nerve fibre layer and optic disc. Results The mean serum ferritin level was 56.98ng/mL in women and 223.82ng/mL in men. After adjusting for age, serum iron, total iron-binding capacity (TIBC), transferrin saturation, white blood cell (WBC) count, high-sensitivity C-reactive protein (HsCRP) and total vitamin D level, males in the highest quartile for serum ferritin level had a higher OR for glaucoma than males in the lowest quartile (OR=1.176, 95% CI 1.030 to 1.342, p=0.016); we did not observe this relationship among women. Other markers of iron metabolism, such as iron level, transferrin saturation and TIBC, and inflammation measures, including WBC, HsCRP and total vitamin D, were not associated with glaucoma. Conclusions High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development.

Original languageEnglish
Pages (from-to)1703-1707
Number of pages5
JournalBritish Journal of Ophthalmology
Volume100
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Ferritins
Glaucoma
Iron
Health
Serum
Population
Transferrin
Vitamin D
C-Reactive Protein
Inflammation
Optic Disk
Ophthalmology
Leukocyte Count
Nerve Fibers
Physical Examination
Oxidative Stress
Leukocytes
Cross-Sectional Studies

Keywords

  • Biochemistry
  • Glaucoma
  • Inflammation
  • Pathology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Relationship between high serum ferritin level and glaucoma in a South Korean population : The Kangbuk Samsung health study. / Gye, Hyo Jung; Kim, Joon Mo; Yoo, Chungkwon; Shim, Seong Hee; Won, Yu Sam; Sung, Ki Chul; Lee, Mi Yeon; Park, Ki Ho.

In: British Journal of Ophthalmology, Vol. 100, No. 12, 01.12.2016, p. 1703-1707.

Research output: Contribution to journalArticle

Gye, Hyo Jung ; Kim, Joon Mo ; Yoo, Chungkwon ; Shim, Seong Hee ; Won, Yu Sam ; Sung, Ki Chul ; Lee, Mi Yeon ; Park, Ki Ho. / Relationship between high serum ferritin level and glaucoma in a South Korean population : The Kangbuk Samsung health study. In: British Journal of Ophthalmology. 2016 ; Vol. 100, No. 12. pp. 1703-1707.
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AB - Background/aims To investigate the association between serum ferritin levels and glaucoma in a South Korean population. Methods This retrospective cross-sectional study included 164029 subjects who underwent screening at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013. All subjects underwent a physical examination, answered sociodemographic and behavioural questions, and provided samples for laboratory analyses. A digital fundus photograph of both eyes was taken, and all photographs were reviewed by ophthalmologists. The ophthalmologists determined if an eye had glaucoma based on criteria set forth by the International Society of Geographical and Epidemiological Ophthalmology and the appearance of the retinal nerve fibre layer and optic disc. Results The mean serum ferritin level was 56.98ng/mL in women and 223.82ng/mL in men. After adjusting for age, serum iron, total iron-binding capacity (TIBC), transferrin saturation, white blood cell (WBC) count, high-sensitivity C-reactive protein (HsCRP) and total vitamin D level, males in the highest quartile for serum ferritin level had a higher OR for glaucoma than males in the lowest quartile (OR=1.176, 95% CI 1.030 to 1.342, p=0.016); we did not observe this relationship among women. Other markers of iron metabolism, such as iron level, transferrin saturation and TIBC, and inflammation measures, including WBC, HsCRP and total vitamin D, were not associated with glaucoma. Conclusions High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development.

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