Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG-PET study

Eun Mi Lee, Ki Chun Im, Ji Hyun Kim, Jung Kyo Lee, Seok Ho Hong, Young Joo No, Sang Ahm Lee, Jae Seung Kim, Joong Koo Kang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 (p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalEpilepsy Research
Volume84
Issue number2-3
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Sclerosis
Scalp
Electroencephalography
Stroke
Temporal Lobe Epilepsy
Temporal Lobe
Putamen
Cerebral Cortex
Extremities

Keywords

  • Dystonic posture
  • Hypometabolism
  • Ictal scalp EEG
  • Mesial temporal lobe epilepsy
  • PET

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis : An FDG-PET study. / Lee, Eun Mi; Im, Ki Chun; Kim, Ji Hyun; Lee, Jung Kyo; Hong, Seok Ho; No, Young Joo; Lee, Sang Ahm; Kim, Jae Seung; Kang, Joong Koo.

In: Epilepsy Research, Vol. 84, No. 2-3, 01.04.2009, p. 187-193.

Research output: Contribution to journalArticle

Lee, Eun Mi ; Im, Ki Chun ; Kim, Ji Hyun ; Lee, Jung Kyo ; Hong, Seok Ho ; No, Young Joo ; Lee, Sang Ahm ; Kim, Jae Seung ; Kang, Joong Koo. / Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis : An FDG-PET study. In: Epilepsy Research. 2009 ; Vol. 84, No. 2-3. pp. 187-193.
@article{a9e966e5831f46f9aa275283a271ed90,
title = "Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG-PET study",
abstract = "This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 (p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.",
keywords = "Dystonic posture, Hypometabolism, Ictal scalp EEG, Mesial temporal lobe epilepsy, PET",
author = "Lee, {Eun Mi} and Im, {Ki Chun} and Kim, {Ji Hyun} and Lee, {Jung Kyo} and Hong, {Seok Ho} and No, {Young Joo} and Lee, {Sang Ahm} and Kim, {Jae Seung} and Kang, {Joong Koo}",
year = "2009",
month = "4",
day = "1",
doi = "10.1016/j.eplepsyres.2009.02.005",
language = "English",
volume = "84",
pages = "187--193",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis

T2 - An FDG-PET study

AU - Lee, Eun Mi

AU - Im, Ki Chun

AU - Kim, Ji Hyun

AU - Lee, Jung Kyo

AU - Hong, Seok Ho

AU - No, Young Joo

AU - Lee, Sang Ahm

AU - Kim, Jae Seung

AU - Kang, Joong Koo

PY - 2009/4/1

Y1 - 2009/4/1

N2 - This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 (p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.

AB - This study was to explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal hypometabolic patterns. Twenty-five patients were classified into 2 groups based on initial ictal discharge (IID) frequency on scalp EEG: (a) those with a sustained regular 5- to 9-Hz rhythm with a restricted temporal or subtemporal distribution (group 1, N = 9); and (b) those with an irregular 2- to 5-Hz rhythm with a widespread distribution (group 2, N = 16). Using statistical parametric mapping, the PET results of each group were compared with age- and sex-matched controls to identify regions of significant hypometabolism, and the clinical characteristics were compared. Group 1 showed focal hypometabolism confined to the ipsilateral temporal lobe, whereas group 2 showed widespread hypometabolism in the ipsilateral temporal lobe, insular cortex and anterior part of the putamen. The two groups showed no significant differences in clinical characteristics. Among semiologic features, dystonic limb posturing was more frequently observed in group 2 (p = 0.03). In summary, scalp EEG IID patterns in HS-MTLE can be important in determining hypometabolic patterns on interictal PET. Differences in hypometabolic patterns may reflect preferential pathways of ictal propagation rather than intrinsic epileptogenic regions.

KW - Dystonic posture

KW - Hypometabolism

KW - Ictal scalp EEG

KW - Mesial temporal lobe epilepsy

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=64149095137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64149095137&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2009.02.005

DO - 10.1016/j.eplepsyres.2009.02.005

M3 - Article

C2 - 19285834

AN - SCOPUS:64149095137

VL - 84

SP - 187

EP - 193

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 2-3

ER -