Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction

Won Kim Jin, Seog Seo Hong, Yong Suh Soon, Ung Choi Cheol, Ju Kim Eung, Seung Woon Rha, Gyu Park Chang, Joo Oh Dong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Lipoprotein(a)(Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis: We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods: In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results: The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion: The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalClinical Cardiology
Volume31
Issue number5
DOIs
Publication statusPublished - 2008 May

Keywords

  • Acute myocardial infarction
  • Lipoprotein(a)
  • Recanalization
  • Thrombolysis in myocardial infarction flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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