Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction

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Abstract

Background: Lipoprotein(a)(Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis: We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods: In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results: The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion: The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalClinical Cardiology
Volume31
Issue number5
DOIs
Publication statusPublished - 2008 May 1

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Lipoprotein(a)
Arteries
Myocardial Infarction
Coronary Angiography
Coronary Artery Disease
Fibrinolysis
Proteins
Thrombosis
Logistic Models
Regression Analysis
Lipids
Pain

Keywords

  • Acute myocardial infarction
  • Lipoprotein(a)
  • Recanalization
  • Thrombolysis in myocardial infarction flow

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{aa075b790b25431f8dabb1dcf6eb3577,
title = "Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction",
abstract = "Background: Lipoprotein(a)(Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis: We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods: In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results: The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion: The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.",
keywords = "Acute myocardial infarction, Lipoprotein(a), Recanalization, Thrombolysis in myocardial infarction flow",
author = "Kim, {Jin Won} and Seo, {Hong Seog} and Soon, {Yong Suh} and Choi, {Cheol Ung} and Kim, {Eung Ju} and Seung-Woon Rha and Park, {Chang Gyu} and Dong, {Joo Oh}",
year = "2008",
month = "5",
day = "1",
doi = "10.1002/clc.20143",
language = "English",
volume = "31",
pages = "211--216",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
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TY - JOUR

T1 - Relationship between lipoprotein(a) and spontaneous recanalization of infarct-related arteries in the early phase of acute myocardial infarction

AU - Kim, Jin Won

AU - Seo, Hong Seog

AU - Soon, Yong Suh

AU - Choi, Cheol Ung

AU - Kim, Eung Ju

AU - Rha, Seung-Woon

AU - Park, Chang Gyu

AU - Dong, Joo Oh

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Background: Lipoprotein(a)(Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis: We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods: In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results: The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion: The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.

AB - Background: Lipoprotein(a)(Lp[a]) is known to inhibit the fibrinolysis system and promote thrombus formation. Hypothesis: We retrospectively investigated the influences of Lp(a) on infarct-related artery patency in the early phase of acute myocardial infarction (AMI). Methods: In 144 patients with ST-segment elevation, myocardial, coronary angiography (CAG) was performed within 12 h of the onset of symptoms. Subjects were divided into 2 groups according to the thrombolysis in myocardial infaction (TIMI) grade, Group I (TIMI 0-1, n = 94) versus Group II (TIMI 2-3, n = 50). The Gensini score and 0- to 3-vessel disease score estimated the severity and extent of coronary artery disease (CAD), respectively. Lp(a), lipid profile and c-reactive protein (CRP) were measured before any medications including thrombolytics were given. Results: The Lp(a) level was higher in Group I than in Group II. There was a weak correlation between Lp(a) level and Gensini score. By multivariate logistic regression analysis, a Lp(a) level was a predictor of infarct-related artery patency in the early phase of AMI. There were no significant differences in the location of the infarct-related arteries, extent of CAD, time from pain to CAG, number of risk factors, and hs-CRP values between the 2 groups. Conclusion: The Lp(a) level was significantly higher in patients with persistent occlusion compared with those with spontaneous recanalization of infarct-related arteries in the early phase of AMI.

KW - Acute myocardial infarction

KW - Lipoprotein(a)

KW - Recanalization

KW - Thrombolysis in myocardial infarction flow

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U2 - 10.1002/clc.20143

DO - 10.1002/clc.20143

M3 - Article

VL - 31

SP - 211

EP - 216

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 5

ER -